Hovelands Degenerative Diseases

Question 0

What is vascular dementia?

Answer 0

• memory loss over time due to less blood flow to the brain
• caused by multiple infarcts or decreased vasculization
• treatment: antiplatelet drugs, control BP and cholesterol, Ginko

Question 1

What is Pick’s disease?

Answer 1

• Ex Vacuo hydrocephalus
• FTLD
• disinhibition, apathy, no empathy, compulsive, hyperorality, no planning

Question 2

What is progressive supra nuclear palsy?

Answer 2

• males over 60
• tau in glial cells and neurofibrillary tangles
• neuronal loss on BG and cerebellum
• caused by FGA, CO,
• truncal rigidity, similar to Parkinson’s
• wheel chair bound in 5 death in 7

Question 3

What is Lewy body dementia?

Answer 3

• Lewy body inclusions without NFTs or amyloid plaques (alpha synuclein)
• Parkinsonism,Brandon cognition, dementia, REM disorder, hallucinations,
• caused by waster build up

Question 4

What is Leigh’s disease?

Answer 4

• PDH def. mtDNA mutations
• 3mo-2yrs
• vomiting, no energy,non apatite,
• prog: complete-1-2, partial-6-7
• treatment - ketones, thiamine, sodium bicarbonate

Question 5

What is Tuberous Sclerosis?

Answer 5

• autosomal dominant causing benign tumors to grow everywhere inside and out
• TSCS1 or 2 –> tumor suppressive gene
• seizures and developmental delay, skin abnormalities
• 75% mortality before age 20
• trouble communicating, raging, trouble with social interaction

Question 6

What is Posterior Cortical Atrophy?

Answer 6

• prosopagnosia, no color, dyslexia, fear of light, blindness, memory loss, anxiety
• posterior cortex atrophies