Household Products Part 1 Flashcards
Name the 2 sources of alcohol toxicosis.
ethanol and methanol
Name the sources of ethanol toxicosis.
ingestion of ethanol containing beverages, fermented bread dough, rotten fruits–inhalation and dermal use of ethanol containing shampoos
Name the sources of methanol toxicosis.
ingestion of methanol containing automotive windshield fluid antifreezes or paint remover
Properties of alcohol?
volatile, irritant, high lipid soluble
What is the oral lethal dose of ethanol and methanol?
4-9 ml/kg
T/F Dogs and cats are the species most commonly intoxicated by alcohols.
FALSE–rarely intoxicated
Diets containing 18-60% glucose have caused ethanol toxicosis d/t yeast fermentation in the GI tract in what species?
calves, lambs and pigs
Ethanol (byproduct of production for fuel) and methanol (antifreeze in oil industry) toxicosis have been reported in what species?
cattle
ADME of alcohol?
A=absorbed orally–food delays absorption
D=widely–including CNS
M=ethanol metabolized by hepatic alcohol dehydrogenase to acetaldehyde–acetaldehyde metabolized by aldehyde dehydrogenase to acetate–acetate converted to acetyl CoA then to carbon dioxide and water
MOA of alcohol toxicosis?
ethanol/methanol cause CNS depression as ethylene glycol and propylene glycol–acetaldehyde has vasodilator action and induces V+–acetate causes metabolic acidosis–ethanol inhibits ADH–irritation of MM
T/F Formic acid accumulation and blindness occur in humans and not dogs.
TRUE!
What are the 2 types of alcohol toxicosis?
acute and chronic
What are the clinical signs of acute alcohol toxicosis?
rapid onset of CNS depression–abnormal behavior such as vocalization, excitement and disorientation–V+ and abnormal breath odor–hypothermia, tremor and ataxia–congested MM
T/F Methanol toxicosis also causes polydipsia and dehydration.
FALSE–ethanol!
What is the cause of death in acute toxicosis?
respiratory failure
What are the clinical signs of chronic alcohol toxicosis?
liver and kidney damage
Postmortem lesions seen in alcohol toxicosis?
congestion of GI mucosa, liver, kidney and lungs
Laboratory diagnosis for alcohol toxicosis?
blood alcohol levels (>1-1.5 g/L ethanol) and hypoglycemia
Is there a specific antidote for ethanol toxicosis? If so, what is it?
NOOOOOO!
Is there a specific antidote for methanol toxicosis? If so, what is it?
YES! ethanol and fomepizole can be used as antidotes
How else can you treat alcohol toxicosis?
emetics in recent ingestion, gastric lavage, activated charcoal (not effective generally), supportive/symptomatic tx