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DD Test 2 LOs > Host-Microbe Interactions > Flashcards

Host-Microbe Interactions Flashcards

1
Q

Infection

A

A microbe enters a relationship with a host. Doesn’t NOT always mean disease

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2
Q

Infectious Disease

A

A disease caused by a microbial organism

Can have various modes of transmission

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3
Q

Pathogenicity

A

The ability of a microbe to cause disease

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4
Q

Virulence

A

Degree of pathogenicity/ability to cause disease

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5
Q

Typical stages in pathogenesis of an infectious disease

A

Encounter, Entry, Spread,Multiplication, Damage, Outcome

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6
Q

Innate Host Defense

A

Phagocytosis

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7
Q

Human Microbiome Composition

A

Skin: Staph, enterobacter
Oropharynx: Step, corynebacterium
GI: Enterococcus, micrococcus, strep, lactobacilli
Vagina: Step, Lactobacilli

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8
Q

Koch’s Postulates

A

Specific Microbes are present regularly in lesions of the disease

Specific microbes can be isolated and gown in vivo

Injection of cultured microbes into animals reproduces the human disease

Specific microbes can be re-isolated from lesions of diseased animals

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9
Q

Communicable Disease

A

Able to be passed patient to patient

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10
Q

Opportunistic Pathogen

A

Microbes that readily cause disease in immunocompromised hosts

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11
Q

Stage of Infection: Encounter

A

How the pathogen met host

Including route of infection/transmission, ID= Infectious Dose

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12
Q

Stage of Infection: Entry

A

How the agent enters the host

How does it colonize? Adhere?

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13
Q

Stage of Infection: Spread

A

How the agent spreads from the site of entry

“Spreading Factors” such as enzymes

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14
Q

Stage of Infection: Multiplication

A

How the agent multiplies in the host

Growth rate

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15
Q

Stage of Infection: Damage

A

How tissue damage is caused by agent/host response

Virulence factors, such as toxins. Inflammatory response

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16
Q

Stage of Infection: Outcome

A

Do microbes win, lose, or coexist?

17
Q

Acquired Host Defense

A

Humoral Immunity, NK Cells

18
Q

Human Microbiome Importance

A

Influences tissue differentiation
Vitamin production
Biochem Conversions (Drug metabolism, metabolite production)
Competition for other pathogens for colonization

19
Q

What affects Microbiome Composition

A

Diet, atbx, anatomic abnormalities, genetics

20
Q

Cholora

A

Disease is caused by endotoxin

21
Q

Pneumococcal Pneumonia

A

Acute inflammation by invasive bacterium

22
Q

Tuberculosis

A

Infection by intracellular bacterium

23
Q

Rheumatic Fever

A

Pathology caused by immune response

DD Test 2 LOs (10 decks)

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