Hormones II Flashcards
Non-polar group of hormones that have receptors inside the cell
Group I
Polar hormones with receptors at the plasma membrane
Group II
The primary messenger in signal transduction pathway
Hormone
Small molecules in complicated networks within the cell which results to signal amplification and alteration of intracellular molecules creating a response
Second messengers
Functions of signaling molecules include the following except:
A. Control cytoskeleton-associated events
B. Modulate ionic composition
C. Regulate cell division
D. Influence cellular metabolism
E. NOTA
E. NOTA
This is a short sequence of DNA that can bind to a specific hormone receptor complex and therefore regulate transcription.
Hormone Response Element
The HRE is found within the ______ of a gene
promoter
Give the “SDAT” group I hormones
Steroid
vitamin D
vitamin A
Thyroid
True or False:
Small uncharged polar molecules are unable to pass the plasma membrane
False:
Although polar, small uncharged molecules are able to pass
The first reaction in the process of Ligand-receptor complex
activation reaction
Glucocorticoid ligand-receptor binding results in the dissociation of:
hsp90
Accelerated gene transcription typically ensues when ________ proteins bind with DNA-bound ligand receptors
coactivator
The tonic repressor of gene transcription in the 2nd mechanism of receptor activation
Receptor-corepressor complex
What kind of hormone is Adapalene
Retinoid
DNA sequence for cAMP
TGACGTCA
DNA sequence for Glucocorticoids, Progestins, Mineralocorticoids, Androgens effectors
GGTACA nnn TGTTCT
inverted repeat
DNA sequence for estrogen effectors
AGGTCA - TGACCT
inverted repeat
DNA sequence for vitamin D, vitamin A and thyroid hormone effectors
AGGTCA n(1-5) AGTCA (direct repeats)
Give the 4 classes of plasma membrane receptors
Ion-channel linked
GPCR
Catalytic receptor
Transmembrane receptor
Mechanism of action of Group II hormones
Generation of Intracellular signals
- Reception
- Transduction
- Response
α subunit of G protein is inactivated when bound to
GDP
Which G protein subunits are connected to the cell membrane?
β and γ
Which of the following is true of G-protein-coupled receptors?
A. They are 7 α-helical hydrophobic cell membrane-spanning domains
B. They are receptors that signal and couple through to effector G-proteins
C. Binds Group II hormones
D. Largest family of cell surface receptors
E. AOTA
E. AOTA
Which of the following does not inhibit Adenylyl cyclase? A, ACh B. β-Adrenergics C. α2-Adrenergics D. Angiotensin II E. Somatostatine
B. β-Adrenergics