Hormone Signaling Pathways Flashcards
1
Q
Insulin uses what signaling pathway?
A
Receptor tyrosine kinase
2
Q
What 3 tissues does insulin affect?
A
Muscle, adipocytes, and liver
3
Q
Insulin resistance is related to phosphorylation of what residues?
A
Serine
4
Q
What are the 3 major domains of nuclear receptors?
A
1) Activation Function 1 domain (AF1)
2) DNA binding domain (DBD)
3) Ligand binding domain (LBD)
5
Q
Where does the DBD bind to on DNA?
A
Hormone response element (HRE)
6
Q
Name an antogonist to the estrogen receptor?
A
Tamoxifen chewed up by Cyt P450 to 4-hydroxy-tamoxifen
7
Q
Epinephrine uses what signaling pathway?
A
GPCR
