Hormone Physiology Flashcards
Gland that has no ducts but have dense capillary network surrounding the secreting cells. It is composed of cells that secrete a chemical substance called hormone. Note that some glands, not considered ______ glands, such as the brain, heart and intestine, also secrete hormones.
Endocrine gland
Gland that has ducts to carry the secretion (non-hormone) to the body surface (eg. sweat) or to cavity another organ. (e.g. digestive enzymes)
- Secretion have extracellular effects such as those that cause digestion of food. Notice that endocrine secretion, unlike exocrine secretions, have intracellular effects.
Exocrine gland
Chemical messenger secreted by endocrine glands into the bloodstream and travel to organs all over the body. May be secreted into the blood by organs not considered endocrine glands such as the heart and intestine. It stimulates physiological functions in cells far away from secreting gland. Binds to target cell receptors located on cell membrane or inside the cell. It causes the target cells to produce new proteins or activate enzymes in target cells. It also causes the cels to increase or decrease a cellular activity.
Hormone
Functions of Hormones
Binds to target cell receptors located on cell membrane or inside the cell.
- It stimulates physiological functions in cells far away from secreting gland.
- It causes the target cells to produce new proteins or activate enzymes in target cells.
- It also causes the cells to increase or decrease a cellular activity.
A chemical messenger secreted by certain cells that travels from one cell to a nearby cell. It stimulates physiological action in these cells. (ie, causes a receptor cell to increase or decrease its activity) It is also known as local hormone and acts as one.
- Hormone released in a certain distance. Small area.
Paracrine.
It is released by neurons. Diffuse across narrow synaptic cleft to receptors on postsynaptic neuron or effectors (muscle or gland). Binds to chemical-gated protein receptors on a postsynaptic neuron or effectors. Once bound to the chemical-gated protein receptor, it causes ion channels on the gated-protein to open and ions move into the cell to change the resting membrane potential.
Neurotransmitter
When a neurotransmitter is secreted by glands such as the adrenal gland, it is called?
Neurohormone
System that does things in nanoseconds (fast acting). Communicated via electrical system and NT. Release NT at synapse of specific cells. Reacts quickly to external stimuli (millisec). Stops quickly when stimulus stops.
Nervous System
System that takes very long to do things. Slow acting. It communicates via hormones. It releases hormones into the bloodstream where it is picked by target cells. It reacts slowly to external stimuli (seconds to day). May continue to respond long after stimulus stops.
Endocrine System
Some chemicals released by the endocrine and non-endocrine glands behaves like hormones and are called _____.
Neurohormones
Examples of Neurohormones. (7)
NE&E. Cholecystokinin. Thyrotropin-releasing hormone. Dopamine. ADH - Antidiuretic hormone (vasopressin) Oxytocin
Neurohormones released by SNS. Can be neuro-T and neuro-H.
NE&E
The endocrine system plays a major role in body ____.
homeostasis
Functions of the Endocrine System. (4)
- It provides the rate at which cells are provided with energy for all their functions. This energy is used in the body’s chemical reaction aka metabolism.
- It regulates the supply of carbohydrate and fatty acids for the body’s metabolism.
- It controls the volume and electrolyte composition of the extracellular fluid.
- It regulates calcium and phosphate for bones and which operate in excitability of nerves and muscles. (Regulate electrons)
Note that low Ca++ leads to _____ and _____; too high Ca++ levels lead to ______.
weak muscles and lethargy
spasms
Major endocrine glands that controls metabolic rate. (2)
Thyroid gland & adrenal medulla.
Major endocrine glands that controls glucose metabolism. (4)
Pancreas, Adrenal cortex and medulla, anterior pituitary.
Major endocrine glands that regulates growth and development. (7)
Anterior pituitary Thyroid Gonads Adrenal cortex Pancreas Skin Kidneys
Major endocrine glands that controls fluid and electrolyte balance. (3)
Posterior pituitary, adrenal cortex and kidneys
Major endocrine glands that controls Ca++ and phosphate balance. (4)
Parathyroid glands, thyroid, skin and kidneys
Major endocrine glands that controls responses to life threatening challenge. (3)
Adrenal cortex and medulla, thymus
Major endocrine glands that controls reproduction and nurturing (5)
Anterior pituitary, ovaries, testes, placenta, pineal gland
The hypothalamus plays a major role in the maintenance of the internal environment by (2)
i. nerve reflex
ii. through the endocrine system
Neurohormones Oxytocin and ADH are made in the ______ and released in the ______.
Hypothalamus; posterior pituitary gland
A part of the CNS that controls thirst and hunger but is also THE MASTER CONTROL OF THE ENDOCRINE SYSTEM.
Hypothalamus
In the hypothalamus, synthesis of posterior pituitary hormones and transport occurs via _____.
nerve axons
In the hypothalamus, thehHypothalamic hormones is carried in the _____________ portal system.
hypothalamohypophyseal
The master endocrine gland and it releases 9 hormones. 2 in the posterior and 7 in the anterior.
Pituitary Gland
The _________ has no direct or nervous link with the hypothalamus. The two are connected via capillaries which pass from the hypothalamus to the pituitary in the pituitary stalk. Hypothalamic hormones are secreted into these capillaries and pass into the _________.
anterior pituitary aka adenohypophysis
The _______ is derived from the base of the brain and consists of neural tissue that has the cell bodies in the hypothalamus and the axons reaching in the _______.
- These axons deliver oxytocin and vasopressin (ADH) synthesized by the hypothalamus.
posterior pituitary aka neurohypophysis
Pituitary hormones are not released in a steady state. GH secreted mainly at ____.
night
Pituitary hormones are not released in a steady state. LH peak at _____.
menstrual cycle
Pituitary hormones are not released in a steady state. Oxytocin surges during _____ and _____.
labor and nursing
The hypothalamus and the cerbral cortex monitor the body’s condition and release hormones or inhibit hormone secretion via a _________.
negative feedback system
The regulation of synthesis and secretion of hormone is mainly through _____. This system of control keeps the hormone levels within a close range. However, this system allows the endocrine glands to respond to environmental and emotional change action on or in the body.
negative/hormone feedback system
The hypothalamus knows that the action is done via _______. They send info about blood up the hypothalamus and pituitary gland. They send info to continue or stop release the hormones.
chemoreceptors
Negative fedback system (4 steps)
- Hypothalamus release hormones to the pituitary gland via releasing hormones,
- The pituitary gland release stimulating hormones to the end organ to stimulate the organ.
- The end organ release the hormones and go to the blood.
- The chemoreceptors detect info from the blood and send info to the hypothalamus/pituitary gland to stop the release of hormones.
From the blood, hormones go to the _____.
target cells
Releasing hormone from the hypothalamus that causes the anterior pituitary gland to release adrenocorticotropic hormone (ACTH) that targets the adrenal cortex to release glucocorticoid secretion and aldosterone secretion.
Corticotrophin-Releasing hormone (CRH)
Releasing hormone from the hypothalamus that causes the anterior pituitary gland to release thyroid stimulating hormone (TSH) that targets the thyroid gland to increase thyroid hormone secretion.
Thyrotropic-Releasing hormone (TRH)
Releasing hormone from the hypothalamus that causes the anterior pituitary gland to release growth hormones that targets most body tissues esp liver to increase growth factor secretion to increase growth.
Growth Hormone releasing hormone (GrRH)
Releasing hormone from the hypothalamus that causes the anterior pituitary gland to decrease the release of growth hormones that targets most body tissues esp liver to decrease growth factor secretion to decrease growth.
Growth Hormone releasinginhibiting hormone (GrIH)
Releasing hormone from the hypothalamus that causes the anterior pituitary gland to release prolactin hormone that targets the breast to increase development of breasts.
Prolactin Releasing hormone (PRH)
Releasing hormone from the hypothalamus that causes the anterior pituitary gland to decrease the release prolactin hormone in the breasts to facilitate secretion of milk.
Prolactin Releasing-Inhibiting hormone (PIH)
Releasing hormone from the hypothalamus that causes the anterior pituitary gland to release Leutenizing hormones (LH) which stimulate the interstial cell. It targets ovaries and testes to increase ovulation and development of corpus luteum in women.
Gonadotrophin-Releasing hormone (GnRH)
Releasing hormone from the hypothalamus that causes the anterior pituitary gland to release Follicle Stimulating Hormone (FSH) that targets ovaries and testes to increase testosterone secretion in men, ovarian follicle growth and spermatogenesis.
Gonadotrophin-Releasing hormone (GnRH)
Releasing hormone from the hypothalamus that causes the middle lobe pf the pituitary gland to release melanocyte stimulating hormones (MSH) that targets the skin to deposit melanin by melanocytes.
Melanocyte stimulating hormone releasing hormone. (MSHRH)
What triggers the release of insulin (beta cells by pancreas) and glucagon (alpha cells by pancreas) to regulate blood glucose?
High blood glucose level. Inhibited by decreased blood glucose level.
What triggers the release of parathyroid hormone (PTH) and 1,25 dihydroxycholecalciferol (by parathyroid and kidney) to regulate plasma concentration of Ca++?
Low Ca++ in the blood.
You have high blood Ca++ level. What endocrine gland is involved and what hormone does it secrete to regulate plasma concentration of Ca++?
Thyroid gland (parafollicular cells) release Calcitonin.
You have low serum Na+ and/or high K+ renin from the kidneys. What endocrine gland is involved and what hormone does it need to secrete to regulate Na+ and K+ serum concentration?
Adrenal Cortex release Aldosterone.
The patient is suffering from hypoxia. What endocrine gland is involved and what hormone does it need to secrete to produce and release RBC?
Kidneys release erythropoietin
The point at which a hormone initially influences the activity of a cell. The hormones act like keys that fit into a specific lock.
The Receptor
Two major groups of hormones.
- Steroid (lipid-soluble) hormones
2. Non-steroid (water-soluble) hormones
Major group of hormone that is from cholesterol and fat. Its made by adrenal gland and gonads. It changes DNA activity. It goes directly inside the cell in which the cell receptor resides. When the hormone receptor binds it goes to the DNA and the DNA opens and we get transcription-translation and we get protein which carries out the work/job. (regulate calcium, etc) It takes a long time to work (slow; 2weeks)
- These hormones are fat-soluble so they penetrate cell wall readily and bind with receptor in the cytosol.
Steroid hormones
What hormone is a non-steroid hormone by type but it BEHAVES like steroid hormones?
Thyroid hormones
Hormones that are small and act by binding to cell membrane receptors. The hormone is the 1st messenger and the cAMP generated by the hormone acts as the 2nd messenger.
Non-steroid hormones aka water-soluble hormones