Hormonal AntiCancer With mechanism

Question 1

Hormonal Anticancers

Asparagine inhibitors

Answer 1

Asparaginase
Pegasparagase

Inhibit Asparaginase that is needed for leukemic cell growth

Fatigue
Poor appetite
Mouth sores
Pancreatitis
Blood clots

Question 2

Estrogen dependant cancers

Aromatase inhibitor

Answer 2

Anastrozole
Letrozole
Essemestane

Inhibit Aromatase that is required to make estrogen.

Fatigue
Osteoporosis
Joint pain
Hot flashes

Question 3

Estrogen dependant cancers
SERMs

Selective estrogen receptor modulator

Answer 3

Tamoxifen
Raloxifen

Bind to estrogen receptors instead of estrogen

Blood clots
Stroke
Endometrial cancer

Question 4

Gonadotropin Releasing hormone Agonist

GnRH agonist

Answer 4

Leuprolide
Goseriline
Triptorelin

Bind to GnRH receptors. Over stimulate them and render them insensitive overtime

Fatigue
Osteoporosis
Joint pain
Hot flashes

Question 5

Gonadotropin Releasing hormone Antgonist

GnRH antgonist

Answer 5

Degarelix

Blocks GnRH receptor

Fatigue
Osteoporosis
Joint pain
Hot flashes

Question 6

Anti androgen

Non steroidal anti androgens

Answer 6

Flutamide
Bicalutamide
Nilutamide

Binds to Androgen receptor (AR) and inhibits exogenous and endogenous testosterones.

Breast enlargement
Sexual dysfunction
Hot flashes
Osteoporosis

Question 7

Anti androgen

Abiraterone

Answer 7

Structural analogue of pregnenolone
Inhibits enzyme CYP17A1, necessary for synthesis of androgen.

Used in high risk castration metastatic prostate cancer

Hot flashes
Osteoporosis
Breast enlargement
Sexual dysfunction