Anti Metabolites Mech

Question 1

Purine Analogues

Adenine Guanine

Answer 1

Mercaptopurine
Hydroxyurea
Fludarabine
Cladribine

Question 2

Mercaptopurine

Answer 2

6 MP

Converts to TIMP . Inhibits IMP transformation to Adenyl succinate & XMP. Inhibits DNA and RNA

Question 3

Hydroxyurea

Answer 3

Ribonucleotide reductase inhibitor

Question 4

Fludarabine

Cladribine

Answer 4

Cladribine —> 2-CdATP and inhibits DNA polymerase and Diribinucleotide reductase

Fludarabine —> F-ara-ATP inhibits diribonucleotide reductase (conversion of AMP to dAMP which is needed for DNA)

Question 5

Pyrimidine analogues
Cytosine
Thymine

Answer 5

Gemcitabine
Capecitabine
Flourouracil (5FU)
Hydroxyurea
Methotrexate

Question 6

Methotrexate

Answer 6

Converts to MTX glutamate

Inhibits dihydrofolate & thymidylate Synthase .

Question 7

Flourouracil

Capecitabine

Answer 7

Converts to 5-FdUMP and inhibits thymidylate Synthase

Capecitabine converts to 5-FU by thymidine synthase.

Question 8

Gemcitabine

Answer 8

Converts to FdFCTP and inhibits DNA synthesis

Question 9

Cytarabine

Answer 9

Converts to Ara-CTP and inhibits DNA synthesis

Question 10

Side effects

Answer 10

Nausea
Vomiting
Mouth sores
Hair Loss

Myelosuppression
( leads to fatigue anemia, bleeding amd increased risk of infection)