Homeostasis Flashcards
Levels of organization of the body
Molecular > cellular tissue > organs > systemic level organismic level
ICF
Intracellular fluids
found in the intracellular compartment
ECF
Extracellular fluids
delivers 02, h20 and nutrients to the cells
also waste his delivered here
fluid found outside the cell
ecf and plasma fluid
ecf fluid is found in the
ecf compartment (icf in icf compartment)
total body fluid is composed of
ecf + ICF
how many % does the total body fluid weigh in adults
60%
how many % is the ICF from the total body fluid
40% (approx 28L in 70kg male)
how many % is the ECF from the total body fluid
20% (5-7% plasma) the rest is intersistial fluid
ECF is called the
Milieu interieur by 19 century Dr. Claude Bernard
this is routiney checked when blood is extracted for examinatio n
ECF
basis for exciteability of nerves and muscles
electrolyte concentration of ECF and ICF
Maintaining nearly constant internal environment through powerful control systens
Homeostasis
greek terms:
Homeos =
Stasis =
Homeos =similar
stasis = standing still
distributes necessary nutrients from the digestive and respiratory systems
cardiovascular system
converts waste products less toxic
liver
excretes waste products
kidneys
this system regulate electrolytes and h20 levels and body fluids
renal system
usually the center of normal range
SET POINT
variable important for blood transport and flow from lungs and digestive.
mean arterial blood pressure
this response reverses the variable, stabilize the effect and returns variable to normal range
NEGATIVE FEEDBACKS
the disturbance in negative feedback
stimulus
the receptors in negative feedbacks
sensors
detectable change in regulated variable picked by the sensor
Stimulus
receives the stimulus signal and relays input signal or information about the change
Sensor
maintains set point conditions and relays signal via efferent pathway and sends signals to effectors
Feedback controller
causes the reversal in biological system to normal range
Effectors
the desired value of the control system
Set point value
difference between input signal from sensor and set point which generates signal to effector to bring back to normal range
Error Signal
Cooling signal in the brain
hypothalamus (anterior)
the heat conservation/ production center of the brain
posterior hypothalamus
adrenal medulla or glands releases this when body is cold
epinephrine
controls skin temperature
peripheral thermoreceptors
core temperature
central thermoreceptors
this organ monitorsblood glucose concentration
Pancreas
glucose sensing mechanisms
islet of langerhans or endocrine cells
Endocrine Beta
secretes insulin
endocrine alpha
secretes glucagon
the sensor of blood pressure homeostatic
baroreceptor
feedback controller of blood pressure
mudulla oblangata
effectors of blood pressure
heart, blood vessels
the catalysis is stopped by the end product
END OF PRODUCT INHIBITION
this response amplifies the variable change
positive feedback
examples of postive feedback
childbirth
blood clotting
ovulation
neuron activation
commands anticipated before they happen
feedforward control
the heart rate increases before the onset of exercise
ex. of feedforward control
complex types of control systems
- adaptive
- feedforward system
- chronic adaptation (exercise physio)
- acclimization (environmental physio)
this organ controls blood glucose concentrations
pancreas
what is the level of sugar after a meal or in the morning
120-140mg/dl
what does Beta cells secrete
Insulin
what is the function of insulin
IT LOWERS BLOOD GLUCOSE ESPECIALLY AFTER A MEAL
IT FACILITATES GLUCOSE TRANSPORT
IT FACILITATES GLUCOSE STORAGE IN THE LIVER AS GLYCOGEN
IT SERVES AS A FEEDBACK CONTROLLER WHICH ACTIVATES THE RELEASEOF INSULIN TO THE BLOODSTREAM
what does alpha cells secrete
glucagon
what is the function of glucagon
FACILITATES GLYCOGEN METABOLISM TO GLUCOSE INCREASING PLASMA GLUCOSE CONCENTRATION
normal fatsing blood sugar level
70-100
when glucagon falls below set point what happens
pancreatic endocrine cells act as sensors
alpha cells secrete glucagon (feedback controllers)
gulacagon is in the blood stream - error signal
CONTROLS THE DEGREE OF CONSTRICTION OF BLOOD
vasomotor centers
what elevates when there is activity in the body
blood pressure
what sensors detect elevated bp
PECIALIZED NERVE ENDINGS OF ARTERIAL WALLS IN THE CIRCULATORY SYSTEM) WHICH IS BARORECEPTOR
THE BRAIN (MEDULLA OBLONGATA) OR HEART CONTROLLERS
CAA- CARDIO ACCELERATORY AREA WHICH INCREASES THE PUMPING ACTIVITY ; CIA- CARDIO INHIBITORY AREA ) AND SERVES AS THE FEEDBACK CONTROLLER
TO DIMINISH THE PUMPING OF THE HEART AND INCREASE BLOOD VESSELS VASODILATION
DECREASES THE ACTIVITY OF THE SYPATHETIC NERVOUS SYSTEM
INCREASES THE ACTIVITY OF THE PARASYMPATHETIC NERVOUS SYSTEM
CHILDBIRTH NEGATIVE FEEDBACK?
no. it is positive
Positive feedback
a process in which the end products of an action cause more of that action to occur in a feedback loop
VASCULAR SPASMS OCCUR WHEN THERE IS A BREAK OR TEAR IN THE BLOOD VESSEL WALLS
- done by platelets
can cause if not stopped by negative feedback
Blood clotting
major loss of blood (2L)
- negative feedback of drop of bp via baroreceptor
- decreased cardiovascular pump
- heart continues to weaken if lose not stopped till cardiac
MASSIVE BLEEDING
INVOLVES CENTRALLY GENERATED FEEDFORWARD COMMAND SIGNALS TO THE MOTOR SYSTEM AND OTHER CONTROL SYSTEMS FOR RESPIRATORY, CARDIOVASCULAR ADJUSTMENTS, THERMAL IGNITION, MOBILIZATION/ UTILIZATION OF ENERGY RESERVES
FEEDFORWARD CONTROL
COMMAND SIGNAL IS GENERATED FROM THE CEREBRAL CORTEX
FEEDFORWARD CONTROL
DELAYED NEGATIVE FEEDBACK CONTROL
IT IS THE INTERACTION OF FEEDFORWARD AND NEGATIVE FEEDBACK LOOPS
ADAPTIVE CONTROL
ENDURANCE TYPE ATHLETES: IMPROVED AEROBIC CAPACITIES OF SKELETAL MUSCLES
RESISTANCE OR SPRINT TYPE ATHLETES: IMPROVED ANAEROBIC CAPACITIES OF SKELETAL MUSCLES
BIOCHEMICAL ADAPTATIONS IN EXERCISE PHYSIOLOGY
ANATOMICAL CHANGES IN EXERCISE PHYSIOLOGY
MUSCLE HYPERTROPHY: SKELETAL MUSCLES AND CARDIAC MUSCLE HYPERTROPHY
INVOLVES PHYSIOLOGIC ADJUSTMENTS TO THE CHANGE IN TEMPERATURE, HUMIDITY, PHOTOPERIOD, OR PH, ALLOWING IT TO MAINTAIN PERFORMANCE ACROSS A RANGE OF ENVIRONMENTAL CONDITION
ACCLIMATIZATION
a sensory receptor primarily found in the hypothalamus o
osmoreceptors
Fick’s Law
Rate of diffusion ∝ surface area × concentration difference thickness of membrane. ∝ means ‘is proportional to’.
DIRECTLT PROPORTIUONAL TO
Inactivation of the sodium-potassium pump (Na,
K-ATPase) will cause:
An increase in the intracellular volume
In Gibbs-Donnan equilibrium
The combination of electrical charge and chemical
concentration gradient across a membrane are in
balance
Symporter
glucose is transported
inside the membrane through a sodium/glucose
transporter. What sort of transporter is it?