Hodgkin's Lymphoma

Question 1

What is the pathology of Hodgkin’s Lymphoma

Answer 1

-Malignancy of the lymphatic system -Involves clonal expansion of B and T white blood cells -BINUCLEATED REED-STERNBERG CELLS

Question 2

What is the aetiology of Hodgkin’s Lymphoma?

Answer 2

-Rare <1500/year -Bimodal distribution 20-35 yrs & 50-60yrs

Question 3

What are the symptoms of Hodgkin’s Lymphoma?

Answer 3

-Painless lymphadenopathy* (cervical chain most common site) Constitutional symptoms: -Fever -Weight loss -Pruritus -Sweats

Question 4

What are the investigations for Hodgkin’s Lymphoma?

Answer 4

Bloods

-FBC, U&E, LFT, LDH, ESR

IMAGING CXR: mass (esp mediastinal) CT scan

HISTOLOGY

• REED-STERNBERG (giant cells)
• Biopsy lymph node
• Bone marrow aspirate & trephine

NB: ARBOR STAGING score

Question 5

What is the management of Hodgkin’s Lymphoma?

Answer 5

Localised Disease (1a IIa) -Radiotherapy to involved lymph node Extensive disease (III IV)/B symptoms present -Chemotherapy Survival rates very variable