HIV/Virus Flashcards
How does prevalence increases?
people get diseases faster and people live longer with the disease
How does prevalence decreases?
people diseases at a slower late, people are cured, people with disease die
equation for incidence
no. new infections/total time experienced for people followed
How does HIV spread?
mucocutaneous contact with blood, semen, vaginal secretion, injection and perinatal transmission (pregnancy, childbirth and breast feeding)
HIV preventions
treatment, prexposure to porphylaxis (PrEP), male circumcision
What enhances HIV transmission?
viral load, disease stage (acute HIV and end stange), male circumcision status, co-infection with STIs
Risk groups for HIV
Men sex with men, people inject drugs, sex workers and sexual partners of these people
HIV prevalence is? incidence?
increase and decrease
What does HIV virus consist of?
lipid bilayer, 2 RNA genome, surface antigen gp120 and gp41, gag gene, pol (integrase, protease, RT), non-structural and regulatory gene
lymphotropic receptor
CXCR4
MACROTROPHIC receptor
CCR5
Reverse Transcritase Inhibitor
Zidovudine –absence of 3’OH
Antiviral therapy
RTi, Pi and Integrase i
initial target of HIV
Langerhans cell