HIV-related Opportunistic Infections

Question 1

PJ Pneumonia: LDH SnSp

Answer 1

Highly Sn 100% in HIV (vs 63% in HIV Neg)

Poorly Sp 47% in HIV (vs 43 in HIV Neg)

Question 2

PJ Pneumonia: LDH Nl Range

Answer 2

140-280 IU/L

Question 3

PJ Pneumonia: Mean LDH

Answer 3

361 IU/L

Question 4

PJ Pneumonia: Mean LDH mortality

Answer 4

447 IU/L

Question 5

Beta-D-Glucan (BG) (Fungitel)

Answer 5

Negative: good for PJP rule out
Sensitive but not specific
Slow turnaround time, not good for acute Dx

Question 6

PJ Pneumonia: Chest CT

Answer 6

Ground glass opacities

Reticular opacities

Question 7

PJ Pneumonia: CXR

Answer 7

Typically abnormal but nonspecific

Pneumatoceles, blebs, fine reticular changes

Question 8

PJ Pneumonia: Onset

Answer 8

Insidious onset in HIV; abrupt onset in HIV Neg

Question 9

PJ Pneumonia: Signs + Symptoms

Answer 9

Fever, nonproductive cough or absence of cough, progressive dyspnea, tachypnea, tachycardia, cellophane rales

Question 10

Viral cause of cutaneous Kaposi Sarcoma

Answer 10

Human herpesvirus 8 (HHV8 or KSHV)

Question 11

2 gamma herpesvirus of human importance

Answer 11

Epstein-Barr Virus and Human herpesvirus 8