Emerging Disease - Monkeypox

Question 1

Monkeypox geographic distribution

Answer 1

Central and Western Africa; mostly Democratic Republic of the Congo

Question 2

Monkeypox expanding distribution

Answer 2

Western Europe and North America

Question 3

Monkeypox genus

Answer 3

Orthopoxvirus

Question 4

Monkeypox first identified

Answer 4

1958 (in monkeys)

Question 5

Monkeypox first described in humans

Answer 5

1970

Question 6

Monkeypox natural reservoir

Answer 6

Unknown, probably African rodents and non-human primates

Question 7

Monkeypox viral prodrome

Answer 7

Fever (85%) (precedes rash by 2 days)
intense headaches (65%)
myalgia (56%)
chills (71%)
lymphadenopathy (71%)
lumbago, intense asthenia (exhaustion)

Question 8

Monkeypox route of transmission

Answer 8

Large droplets (hours of close exposure), lesional contact and contaminated body fluids, contaminated bedding

Question 9

Monkeypox incubation time

Answer 9

6-12 days, up to 21 days

Question 10

Monkeypox cutaneous distribution

Answer 10

Face (95%)
Palms/soles (70%)
Oral mucosa (70%)
Genitals (30%)
Conjunctiva (20%)
Proctitis

Question 11

Monkeypox case fatality

Answer 11

3-6%

Question 12

Monkeypox lesion progression

Answer 12

Macule–>papule–>vesicle–>pustule–>crusting

Question 13

Monkeypox typical course

Answer 13

Self-limited 2-4 weeks

Question 14

Monkeypox vaccines (3)

Answer 14

JYNNEOS (2019)
ACAM2000 (2007)
Dryvax (1931)

Question 15

Monkeypox live replicating vaccine(s)

Answer 15

ACAM2000 + Dryvax

Question 16

Monkeypox live non-replicating vaccine(s)

Answer 16

JYNNEOS