HIV Pharm

Question 1

Drug class that integrates into growing viral DNA stran

Answer 1

NRTI

Question 2

Drug class that binds to HIV reverse transcriptase, halting the synthesis of viral DNA

Answer 2

NNRTI

Question 3

Drug class that inhibits viral aspartate protease, preventing the cleavage of viral gag and pol peptides

Answer 3

Protease inhibitors (-navir suffux)

Question 4

Drug class that inhibits the covalent bonding of HIV and human DNA by binding integrase

Answer 4

INSTI i.e integrase inhibitor (-gravir suffix)

Question 5

Drug class that inhibits the function of gp41

Answer 5

Fusion inhibitor

Question 6

Drug class that inhibits the function of gp120

Answer 6

CCR5 blocker

Question 7

NRTI that is a thymidine analogue;

Bone marrow suppression, skeletal muscle myopathy, used to be used in pregnant women

Answer 7

Zidovudine

Question 8

NRTI that is a thymidine analogue;

Peripheral neuropathy, lipodystrophy

Answer 8

Stavudine

Question 9

NRTI that is a cytosine analogue;

hyperpigmentation in palms and soles

Answer 9

Emtricitabine

Question 10

NRTI that is a cytodine analogue;

Low toxicity, approved for tx of naive pts

Answer 10

Lamivudine

Combo tx for naive pts is Lamivudine + Dolutegravir

Question 11

NRTI + INSTI combo tx for naive patients

unless viral load is high

Answer 11

Lamivudine + Dolutegravir

Question 12

The superior 2x NRTI combo

Answer 12

Tenofovir + Emtricitabine

Question 13

NRTI that is a guanosine analogue;

Toxic to people with HLA-B*5701

Answer 13

Abacavir

Question 14

NRTI that is an adenosine analogue;

Fanconi syndrome

Answer 14

Tenofovir disoproxil fumurate (TDF)

Question 15

NRTI that is an adenosine analogue;

Better tolerated but causes weight gain

Answer 15

Tenofovir alafenamide (TAF)

Question 16

NRTI that is an adenosine analogue;

Peripheral neuropathy and pancreatitis

Answer 16

Didanosine

Question 17

INSTI associated with immune reconstitution and rhabdomyolysis, ok to use in tx naive patients

Answer 17

Raltegravir

Question 18

Drug class used as the primary +1 to 2x NRTIs

Answer 18

INSTI

Question 19

INSTI that is glucoronidated before renal excretion and first choice for naive pts, avoid in pregnant patients

Answer 19

Dolutegravir

Question 20

INSTI that is glucoronidated before renal excretion and is metabolized by CYP3A4, most readily absorbed INSTI

Answer 20

Bictegravir

Question 21

Weight gain is most associated with which drug class

Answer 21

INSTI

Question 22

Lactic acidosis is most associated with which drug class

Answer 22

NRTI

Question 23

Which drug class is metabolized by CYP3A4 and needs to be boosted with ritonavir/cobicistat

Answer 23

Protease inhibitor

Question 24

Which drug class is a substrate for p-glycoprotein, potentially influencing other drugs

Answer 24

Protease inhibitor

Question 25

PI no longer used due to pill burden and GI side effects

Answer 25

Saquinavir

Question 26

PI associated with renal stones

Answer 26

Indinavir

Question 27

PI that is a sulfa drug

Answer 27

Darunavir

Question 28

PI associated with jaundice due to UCB, current first choice in class

Answer 28

Atazanavir

Question 29

PI that often works after others have failed

Answer 29

Lopinavir

Question 30

CYP3A4 inhibitors (2)

Answer 30

Ritanovir > Cobicistat

Question 31

NNRTI that must be combined with other drugs due to high potential for resistance

Answer 31

Nevirapine

Question 32

NNRTI associated with CNS/psych side effects, formerly considered teratogenic

Answer 32

Efavirenz

Question 33

NNRTI that still works after mutations that disrupt function of other NNRTI

Answer 33

Etravirine

Question 34

NNRTI resistant to common mutation, needs to be taken with a meal

Answer 34

Rilpivirine

Question 35

NNRTI with low side effects, considered current best in class

Answer 35

Doravirine

Question 36

Fusion blocker for tx experienced adults that is administered parenterally

Answer 36

Enfuvertide

Question 37

CCR5 blocker

Answer 37

Maraviroc