Cancer Pharm

Question 1

Inhibits dihydrofolate reductase;
Folate analog;
Toxicity causes GI and bone marrow problems

Answer 1

Methotrexate

Question 2

Reversal of Methotrexate toxicity

Answer 2

Leucovorin

Question 3

Alkylating agent (nitrosiurease);
inter and intrastrand covalent links with DNA;
lipophilic and able to cross BBB to tx glioblastoma

Answer 3

Carmustine

Question 4

Antimitotic agent (M phase);
Binds B tubulin;
Prevents microtubule polymerization

Answer 4

Vinca Alkyloids: Vinblastine, Vincristine

Question 5

Antimitotic agent (M phase);
Binds B tubulin;
Promotes microtubule polymerization;
Prevents microtubule depolymerization

Answer 5

Taxanes: Paclitaxel

Question 6

Antimitotic agent (M phase);
Binds B tubulin;
Promotes microtubule polymerization;
Prevents microtubule depolymerization

***avoids resistance due to p-glycoprotien

Answer 6

Cabazitaxel

Question 7

Antitumor Abx;

Produces free radicals that can damage the heart

Answer 7

Doxorubicin

Question 8

Antitumor Abx;

Produces free radicals that can damage the lungs

Answer 8

Bleomycin

Question 9

Peptide that mimics VEGFR;

Binds VEGF, inhibiting angiogenesis

Answer 9

Ziv-alfibercept

Question 10

Monoclonal Ab that binds VEGF, inhibiting angiogenesis

Answer 10

Bevacizumab

Question 11

Inhibits tyrosine kinase domain of BCR-ABL fusion protein;

Tx for CML w/ t(9:22)

Answer 11

Imatinib

Question 12

Purine analog that inhibits purine synthesis;
Metabolized to active form by HGPRT;
May also be metabolized by xanthine oxidase

Answer 12

6-Mercaptopurine

Question 13

Dose of oral 6-MP must be reduced in pts also taking _______ due to the drug increasing the bioavailability of 6-MP

Answer 13

Allopurinol

(inhibited xanthine oxidase increases bioavailibility of 6-MP as more is shunted to HGPRT to transform into active cytotoxic agent)

Question 14

Drugs susceptible to p-glycoprotein resistance (increased MDR1 expression)

Answer 14

Natural products (from bacteria or plants)

• Anthrocyclines (doxyrubicin)
• Vinca Alkyloids
• Etoposide
• Paclitaxel
• Dactinomycin

Question 15

Doxyrubicin MOA

Answer 15

topoisomerase II inhibitor (inhibit DNA replication)

Question 16

Etoposide MOA

Answer 16

topoisomerase II inhibitor (inhibit DNA replication)

Question 17

Dactinomycin MOA

Answer 17

binds C-G base pairs in DNA, preventing RNAP activity