Derm Path

Question 1

Benign neoplasm due to RAS or BRAF mutation that undergoes growth arrest due to p16/INK4a activity

Answer 1

Melanocytic nevus

Question 2

Melanoma precursor due to CDKN2A or CDK4 gene mutation

Answer 2

Dysplastic nevus

Question 3

Most common mutations in melanoma

Answer 3

BRAF and TERT

Question 4

Thickened, hyperpigmented, velvet like texture in flexural areas; associated with obesity and diabetes; paraneoplastic process assoc. with GI adenocarcinomas

Answer 4

Acanthosis nigricans

Question 5

Gene mutation in acanthosis nigricans and seb k

Answer 5

FGFR3

Question 6

Gene mutation in Cowden syndrome (trichilemmomas)

Answer 6

PTEN, increased risk of breast ca.

Question 7

Turban tumor caused by what gene mutation

Answer 7

CLYD (tumor suppressor)

Question 8

ductal differentiation of forehead or scalp; jigsaw puzzle on histo

Answer 8

Cylindroma

Question 9

Pilomatricoma gene mutation

Answer 9

CTNNB1

Question 10

Cutaneous horn with dyskeratosis, elastosis and parakeratosis; precursor to SCC

Answer 10

Actinic keratosis

Question 11

SCC mutations

Answer 11

p53, RAS, Notch

Question 12

BCC mutation

Answer 12

PTCH (hedgehog pathway)

Question 13

Pearly papule with telangectasias and peripheral palisading on histo

Answer 13

BCC

Question 14

Dermatofibrosarcoma gene mutation

Answer 14

COL1A1 and PDGFB

Question 15

Protuberant nodule with storiform (pinwheel) fibroblasts

Answer 15

Dermatofibrosarcoma Protuberans

COL1A1 and PDGFB

Question 16

CD4 cells in the skin, cutaneous T-cell lymphoma, Pautrier microabscesses

Answer 16

Mycosis Fungioides

Question 17

Type 4 HSR skin condition, caused by external or ingested Ag, causes spongiosis

Answer 17

Acute Eczematous Dermatitis

Question 18

Keritinocyte injury caused by CD8 T cells reacting to infection/drugs etc. Targetoid lesions that are self limiting

Answer 18

Erythema multiforme

Question 19

Pink-salmon colored plaques on extensor surfaces, Munro microabcesses (PMN aggregates) and + Auspitz sign, nail pitting

Answer 19

Psoriasis

Question 20

Inflammation of epidermis, increased sebum production due to androgens, associated with parkinsons (replace dopamine improves skin condition), follicular lipping on histo

Answer 20

Seborrheic dermatitis

Question 21

Pruritic, purple, polygonal, planar, papules and plaques; itchy violaceous papules with Wickham striaw; sawtoothing on histo; koebner phenomenon and SCC risk

Answer 21

Lichen planus

Question 22

Pemphigus where IgG attacks desmoglein diffusely, tombstones on histo, fishnet on immunoflorescence

Answer 22

Pemphigus vulgaris

Question 23

Pemphigus where IgG attacks superficial Dsg1

Answer 23

Pemphigus foliaceus

Question 24

Subepidermal blisters due to Ab against BPAGs

Answer 24

Bullous pemphigoid

Question 25

Grouped vesicles on extensor surfaces; associated with celiac dz; IgA cross react with reticulin and cause subepidermal blister

Answer 25

Dermatitis herpetiformis

Question 26

Group of disorders where inherited defects in structural proteins cause blisters at sites of pressure, rubbing or trauma

Answer 26

Epidermolysis bullosa

Question 27

Comedones caused by androgens and Propionibacterium acnes

Answer 27

Acne vulgaris

Question 28

Very tender panniculitis caused by B-hemolytic strep and TB

Answer 28

Erythema nodosum

Question 29

HPV subtypes that are related to SCC

Answer 29

HPV 5 & 8

Question 30

Impetigo pathogenesis

Answer 30

S. aureus toxin cleaves desmoglein 1