HIV - MC

Question 1

HIV infects cells expressing…

Answer 1

CD4 receptors

Question 2

What is present on the surface of the cells?

Answer 2

Infection via glycoprotein 160 on HIV w/ CD4 & chemokine coreceptors

Question 3

What is the hallmark of untreated HIV?

Answer 3

Profound CD4 T-lymphocyte depletion & severe immunosuppression

Question 4

What is the current goal of combination antiretroviral therapy (ART)?

Answer 4

• Suppression of HIV replication

- Increase in CD4 lymphocytes

Question 5

What is initial tx for HIV?

Answer 5

Minimum of 3 active antiretroviral agents from at least 2 drug classes

Question 6

What does the 1st HIV regimen include?

Answer 6

2 NRTIs + INSTI, an NNRTI, or a PI boosted w/cobicistat orritonavir

*Cobicistat & Ritonavir increase the effectiveness of the PI

Question 7

What website will give you info regarding the regimens for HIV meds?

Answer 7

https://aidsinfo.nih.gov/understanding-hiv-aids/fact-sheets/21/58/fda-approved-hiv-medicines/

Question 8

What are short-term effects of HIV meds?

Answer 8

• N/V/D
• Fever, fatigue
• HA, muscle pain
• Dizziness

Question 9

What are long-term effects of HIV meds?

Answer 9

• Lipodystrophy
• HLD
• Osteoporosis

Question 10

Do “virs” interact w/ other “virs”?

Answer 10

YASSS HONAY

Question 11

What antiretroviral agents are safe in pregnancy?

Answer 11

• NRTIs: Lamivudine, zidovudine
• NNRTIs: Nevirapine
• PIs: Lopinavir/ritonavir, atazanavir/ritonavir

Question 12

Which 3 vaccines (w/ live viruses) are contraindicated in HIV pts?

Answer 12

• MMR
• VAR
• HZV