Hepatitis C - EG Flashcards
How is Hepatitis C transmitted?
blood-borne pathogen
- IVDU, renal dialysis, body piercings and tattoos
What medical condition is associated with HCV over 20-30 years?
cirrhosis
USPSTF recommends screening all patients for HCV between
1945-1965
How do therapeutic targets against HCV work
interrupt the process of RNA replication
what is the one Hepatitis virus that is DNA
HBV
What are the major classes of drugs for HCV
NS5B Neucleos(t)ide - Sofosbuvir all 6 genotypes
NS5B non-neucleos(t)ide
NS5A inhibitor
NS3/4A protease inhibitors - Grazoprevir, Glecaprevir
Which laboratory tests are recommended at any time prior to starting antiviral therapy?
HCV genotype and subtype (which therapy)
Quant HCV RNA aka viral load (how long)
Recommended lab tests w/in 12 wks of starting therapy?
CBC INR ALT AST GFR
All pt’s initiating HCV antiviral therapy should also be assessed for…
HBV coinfection and for evidence of prior infx
What lab value would prompt discontinuation of HCV therapy?
10x increase in ALT at any time during tx
less than 10x + sxs or other abnormal labs
Quant HCV viral load testing is recommended…
after 4 weeks of therapy and 12 weeks after completion of therapy
T or F: antiviral drug therapy should be interrupted or discontinued if HCV RNA levels are not performed or available during tx.
FALSE.
should NOT be interrupted/discontinued
Sofosbuvir ADE’s
fatigue, headache, asthenia
Ledipasvir, Elbasvir, Velpatasvir, pibrentasvir ADE’s
fatigue, headache
Simeprevir ADE’s
rash (sulfonamide moiety)
photosensitivity
