HIV Brands

Question 1

HIV Life cycle

7 steps

Answer 1

1. Binding & Attachment
2. Fusion
3. Reverse Transcription
4. Integration
5. Transcription and Translation
6. Assembly
7. Budding and Maturation

Question 2

Atripla

Answer 2

Efavirenz
Emtricitabine
TDF

Question 3

Complera

Answer 3

Rilpivirine
Emtricitabine
TDF

Question 4

Stribild

Answer 4

Elvitegravir
Cobicistat
Emtricitabine
TDF

Question 5

Genvoya

Answer 5

Elvitegravir
Cobicistat
Emtricitabine
TAF

Question 6

Triumeq

Answer 6

Dolutegravir
Abacavir
Lamivudine

Question 7

Biktarvy

Answer 7

Bictegravir
Emtricitabine
TAF

Question 8

Epzicom

Answer 8

Abacavir

Lamivudine

Question 9

Descovy

Answer 9

Emtricitabine

TAF

Question 10

Truvada

Answer 10

Emtricitabine

TDF

Question 11

NRTI Mechanism

Answer 11

bind enzyme reverse transcriptase, results in DNA chain termination

Question 12

Abacavir

• box warning
• class

Answer 12

test for HLA-B 5701 (do not use if +)

NRTI

Question 13

Lamivudine

• box warning
• class

Answer 13

dont use HepB formulation (leads to viral resistance)

NRTI

Question 14

Emtricitabine

• Box warning
• class

Answer 14

Must confirm HIV neg if used for prep

NRTI

Question 15

TDF

• Warning
• class

Answer 15

Tenofovir Disoproxil Fumarate (Viread)
Fanconi Syndrome (ostomalacia/bone density)
Check Renal Function before
NRTI

Question 16

TAF

• Warning
• Class

Answer 16

Tenofovir Alafenamide
Fanconi Syndrome (ostomalacia/bone density)
Less Renal and bone toxicity than TDF
NRTI

Question 17

NRTI Drug Interactions

Answer 17

• TAF is P-gp substrate

- Didanosine + Allopurinol

Question 18

NNRTI Class Mechanism

Answer 18

Non-competitive binding to reverse transcriptase, blocks RNA and DNA dependent DNA polymerase activity

• hepatotoxicity
• CYP 450 inducers
• No renal adjustment

Question 19

Efavirenz

• Warning
• Class

Answer 19

Serious Psychiatric Symptoms & QT prolongation

NNRTI

Question 20

Rilpivirine

• Warning
• Class

Answer 20

do not use with PPIs, requires acidic environment
QT prolongation
NNRTI

Question 21

Protease Inhibitors Class Mechanism

Answer 21

inhibit HIV protease, resulting in non-functional viral proteins that prevents assembly and maturation of virions

• all end in “Navir”
• Must take with Booster (ritonavir or cobicistat)

Question 22

Darunavir

• warning
• Class

Answer 22

Drug-induced hepatitis, serious skin reactions

PI

Question 23

Atazanavir

• warning
• class

Answer 23

PR interval prolongation, serious skin reaction or hepatotoxicity
PI

Question 24

Pharmacokinetic Boosters

- which drugs

Answer 24

Ritonavir

Cobicistat

Question 25

Ritonavir - Warnings - Class

Answer 25

Many drug-drug interactions, take with food | PI/PK booster

Question 26

Cobicistat

Answer 26

Less interactions than ritonavir, take with food | PI/PK booster

Question 27

Integrase Strand Transfer Inhibitor Mechanism

Answer 27

Blocks integrase enzyme needed for viral DNA to integrate w/ host DNA - end in "tegravir"

Question 28

Elvitegravir - warning - class

Answer 28

Acute exacerbation of HBV | Integrase Inhibitor

Question 29

Bictegravir - warning - Class

Answer 29

acute exacerbation of HBV | Integrase Inhibitor

Question 30

Dolutegravir (Brand) - warning - class

Answer 30

Tivicay DO NOT combine with dofetilide; Insomnia & SCr increase Integrase inhibitor

Question 31

Raltegravir (Brand) - Warning - Clas

Answer 31

Isentress Inc CPK, Myopathy or Rhabdomyolosis Integrase Inhibitor

Question 32

CCR5 antagonist mechanism

Answer 32

Inhibits binding to the CCR5 co-receptor on CD4 cells that prevents HIV from entering cells

Question 33

Maraviroc (Brand) - Warning - Class

Answer 33

Selzentry Hepatotoxicity, no use in sever renal impairment CCR5 antagonist