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Naplex Stuff > Chemo Drugs > Flashcards

Chemo Drugs Flashcards

1
Q

Cyclophosphamide (Brand)
Reversal:
Major Toxicity:
MoA:

A

Cytoxan
Reversal Agent - Prophylactic Mesna if >1g/m2
Major Toxicity - Hemorrhagic cystitis
Other Toxic - Skin/SJS; SIADH, infection reactivation
MoA - Alkylating Agent: Cross-links DNA strands and inhibits protein synthesis and DNA synthesis

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2
Q

Ifosfamidem (Brand)
Reversal:
Major Toxicity:
MoA:

A

Ifex
Reversal Agent - Prophylactic Mesna if >1g/m2
Major Toxicity - Hemorrhagic cystitis
Other Toxic - Skin/SJS; SIADH, infection reactivation
MoA - Alkylating Agent: Cross-links DNA strands and inhibits protein synthesis and DNA synthesis

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3
Q

Carmustine (Brand)
Notes
Major Toxicity:
MoA:

A

BiCNU, Gliadel Wafer
must use non-PVC bag/tube
Major Toxic - Pulmonary Toxicity
MoA - Alkylating Agent: Cross-links DNA strands and inhibits protein synthesis and DNA synthesis

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4
Q

Bendamustine
Major Toxicity:
MoA:

A

Bendeka, Treanda
Major Toxic - Hepatotoxicity
MoA - Alkylating Agent: Cross-links DNA strands and inhibits protein synthesis and DNA synthesis

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5
Q

Busulfan
Major Toxicity:
MoA:

A

Myleran, Busulfex
Major Toxic - Pulmonary Toxicity
MoA - Alkylating Agent: Cross-links DNA strands and inhibits protein synthesis and DNA synthesis

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6
Q

Melphalan
Major Toxicity:
MoA:

A

Alkeran, Evomela
Major Toxic - Myelosuppression
MoA - Alkylating Agent: Cross-links DNA strands and inhibits protein synthesis and DNA synthesis

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7
Q

Cisplatin
Notes
Major Toxicity:
MoA:

A

Dose limited to <100mg/m2/cycle; risk of anaphylaxis w/ repeat exposure
Major Toxicities - Neuropathy, Nephrotoxicity, Ototoxicity
MoA - Platinum-based compounds, cross-link DNA and interfere w/ DNA synthesis & Cell replication

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8
Q

Carboplatin
Notes
Major Toxicity:
MoA:

A

Risk of anaphylaxis w/ repeat exposure
Major Toxicities - Neuropathy, Nephrotoxicity, Ototoxicity, Highly Ematogenic
MoA - Platinum-based compounds, cross-link DNA and interfere w/ DNA synthesis & Cell replication

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9
Q

Doxorubicin
Notes/Protectant
Major Toxicity:
MoA:

A

Adriamycin
Cumulative lifetime dose of 450-550 mg/m2; Dexrazoxane as chemoprotectant
ADR - red urine discoloration
Major Toxicity - Myocardial Toxicity, Vesicant, Myelosuppression
MoA - Anthracylcine, Intercalation into DNA, inhibiting topoisomerase II, creates oxygen free radicals

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10
Q

Mitoxantrone
Notes/Protectant
Major Toxicity:
MoA:

A

Dexrazoxane as chemoprotectant
ADR - Blue urine discoloration
Major Toxicity - Myocardial Toxicity, Myelosuppression, Secondary Malignancy
MoA - Anthracylcine, Intercalation into DNA, inhibiting topoisomerase II, creates oxygen free radicals

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11
Q

Vincristine
Notes
Major Toxicity:
MoA:

A

Not myelosuppressive, capped at 2mg/dose
Major Toxic - CNS toxicity Neuropathy
MoA - Inhibit function of microtibules during M phase (

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12
Q

VinBlastine
Notes
Major Toxicity:
MoA:

A

Myelosuppresive,
Major Toxic - Bone marrow toxicity
MoA - Inhibit function of microtibules during M phase (

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13
Q

Paclitaxel
Notes
Major Toxic
MoA

A

Severe Hypersensitivity Rxns
Peripheral Sensory Neuropathy & Hypersensitivity
Inhibit function of Taxane - microtubules during M phase

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14
Q

Docetaxel
Notes
Major Toxic
MoA

A

Severe Hypersensitivity Rxns
Peripheral Sensory Neuropathy & Hypersensitivity
Taxane - Inhibit function of microtubules during M phase

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15
Q

Cabazitaxel
Notes
Major Toxic
MoA

A

Severe Hypersensitivity Rxns
Peripheral Sensory Neuropathy & Hypersensitivity
Taxane - Inhibit function of microtubules during M phase

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16
Q

Irinotecan
Notes
Major Toxic
MoA

A

May cause Acute cholinergic symptoms
Major - Diarrhea (early and late)
Topoisomerase 1 inhibtor, blocks coiling and uncoiling of dsDNA during S phase

17
Q

Etoposide
Notes
Major Toxic
MoA

A

Infusion related hypotension is common
Major - Myelosuppresion
Topoisomerase II inhibitor, blocks coiling and uncoiling of dsDNA during G2 phase

18
Q

Fluorouracil (5fU)
Notes
Major Toxic
MoA

A

Give with Leucovorin, if DPD deficiency inc risk of toxicity
Major - Inc INR, Handfoot syndrome
Pyrimidine analog antimetabolite, Inhibit pyrimidine synthesis during S-phase

19
Q

Capecitabine (Xeloda)
Notes
Major Toxic
MoA

A

Prodrug of 5FU
DPD deficiency inc risk of toxicity
Major - Inc INR, Handfoot syndrome
Pyrimidine analog antimetabolite, Inhibit pyrimidine synthesis during S-phase

20
Q

Methotrexate
Notes
Major Toxic
MoA

A

high doses require leucovorin rescue
Major - Nephrotoicity and Hepatotoxicity
interfere w/ Folic acid cycle blocking purine and pyrimidine biosynthesis during S phase

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