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Naplex Stuff > Chemoman and Reversal Agents > Flashcards

Chemoman and Reversal Agents Flashcards

1
Q

Drugs that cause Myelosuppression

A

All except Bleomycin & Vincristine

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2
Q

Chemo drugs Nausea and Vomiting

A

Cisplatin
Cyclophosphamide
Ifosfamide

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3
Q

Chemo drugs that cause Mucositis

A

5FU
Capecitabine
Irinotecan
Methotrexate

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4
Q

Diarrhea

A

5FU
Capcetabine
Irinotecan

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5
Q

Chemo drug that causes Constipation

A

Vincristine

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6
Q

Xerostomia

A

Radiation Therapy

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7
Q

Chemo agents that cause Cardiotoxcicity

A

Anthracyclines
e.g. Doxorubicin
TKIs

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8
Q

Chemo agents that cause Pulmonary Fibrosis

A

Bleomycin
Busulfan
Carmustine
Lomustine

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9
Q

Pneumonitis

A

Methotrexate

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10
Q

Chemo agents that cause Hepatotoxicity

A 
Antiandrogens
e.g. Bicalutamide
Antimetabolites 
e.g. methotrexate, cytarabine
TKIs
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11
Q

Chemo agents that cause Nephrotoxicity

A

Cisplatin

Methotrexate

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12
Q

Agents that cause Hemorrhagic Cystitis

A

Ifosfamide

Cyclophosphamide (>1g/m2)

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13
Q

Chemo agents that cause Neuropathy

A

Platinum Drugs
Vinca Alkaloids
Proteasome Inhibitors

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14
Q

Thromboembolic Risk

A

Aromatase Inhibitors

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15
Q

Ototoxicity

A

Cisplatin

Carboplatin

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16
Q

Cisplatin Adjunct agent

A

Amifostine - prevents nephrotoxicity

17
Q

Doxorubicin/Anthracycline adjunct agent

A

Dexrazoxane - prevents cardiomyopathy, treats exttravasation

18
Q

Fluorouracil Adjunct agent

A

Leucovorin - ehances efficacy (cofactor)

19
Q

Fluorouracil or Capecitabine Adjunt agent

A

Uridine Triacetate - antidote for severe early onset toxicity

20
Q

Ifosfamide/Cyclophosphamide adjunct agent

A

Mesna, prevents hemorrhaic cystitis

21
Q

Irinotecan adjunct agent(s)

A

Atropine & Loperamide, prevent or treat delayed/acute diarrhea

22
Q

Methotrexate adjunct agent(s)

A

Leucovorin, given after to decrease myelosuppresion and as antidote of mucositis

Glucarpidase, in acute renail failure/high concentrations

23
Q

Vinca Alkyloid adjunct agent

A

Hyaluronidase

24
Q

High Risk Emetic Therapy

A

NK1-RA”-pitant” + Steroid + 5HT-RA

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