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Immunology And Serology > HIV > Flashcards

HIV Flashcards

0
Q

Viruses belong to the subfamily Oncovirinae

A

HTLV1
HTLV-2
HTLV-5

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1
Q

HIV belongs to what subfamily?

A

Lentivirinae

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2
Q

gp 120- aid in the fusion and attachment of HIV to CD4+ cells

A

Env Gene

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4
Q

Other name for HIV

A

HTLV-3 (human Tcell lymphotropic virus type 3)
LAV (Lymphadenopathy associated virus)
ARV (AIDS associated retrovirus)

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5
Q

Most common subtype of Group M

A

Subtype C

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6
Q

Three layer structure of HIV

A

P24
gp41
gp120

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7
Q

HIV Naked or enveloped?
Icosahedral or complex?
With or without spikes?

A

Envelope
Icosahedral
With spikes

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8
Q

Enzyme present in Retroviridae

A

Reverse transcriptase

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9
Q

Diagnostically important proteins

A

p24
gp41
gp120
gp160

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11
Q

Transcribe RNA to DNA

A

Reverse transcriptase

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12
Q

Strains that can infect both macrophages and T cells

A

M tropic or R5

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13
Q

The three main structural gene of HIV

A

Env gene
Gag gene
Pol gene

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15
Q

Viral genetic material that is incorporated to the DNA of the host cell

A

Provirus

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16
Q

Group antigen gene that is found in nucleocapsid

A

p15
p17
p24

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17
Q

Receptor to the host

A

CD4

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18
Q

Positive dried smear of HIV remain infectious for? How about HBV smear?

A

3days

7days

19
Q

HIV viruses that preferentially infect T cells

A

T tropic or X4 strain

20
Q

Inserts viral DNA to host DNA

A

Integrase

22
Q

Chemokine receptor of HIV required to enter T cells

A

CXCR4

23
Q

This is used to inactivate HBV and HIV

A

HBV- 10% bleach for 10mins

HIV- 10% bleach for 3mins

24
Q

First antibody to be produced following HIV infection

A

anti p24

26
Q

Confirmatory test for HIV

A

Western blot

27
Q

Receptor to the virus

A

gp120

28
Q

MOT of HIV

A

Sexual
Perinatal
Parenteral

30
Q

End stage of HIV infection

A

AIDS

31
Q

Treatment for HIV that involves aggressive combination therapy

A

HAART

Highly active anti retroviral therapy

32
Q

Classify HIV-1 and HIV-2 according to distribution

A

HIV1 global or pandemic

HIV2 west Africa

33
Q

Testing is often done at _____, ______,&_______ after exposure to find out if a person is infected with HIV

A

6wks
3months
5months

34
Q

Screening test for HIV

A

Elisa
RIA
Agglutination test

35
Q

Chemokine receptor of HIV required to enter macrophages

A

CCR5

45
Q

Cleaves structural protein located in the core near the nucleic acid

A

Protease

46
Q

The three subgroups of HIV 1

A

Group M
Group N
Group O

Immunology And Serology (5 decks)

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