Cytokines, Complement, Immuno Disorders Flashcards
Regulates immune response
Cytokines
Small soluble proteins that regulate the immune system
Cytokines
Endogenous pyrogen and induces fever in the acute phase reactants. Produced by macrophages
Interleukin 1
Has cytotoxic activity against tumor cells and virally infected cells
Tumor necrosis factor - TNF
TNF that produced by macrophages. Also called cachetin
TNF alpha
TNf that produced by CD47 and CD8. Also called lymphotoxin
TNF beta
Stimulates B cells to proliferate and differentiate into plasma cells and induces CD4+ T cells to produce greater quantities of both pro and anti inflammatory cytokines
Interleukin 6
For activation and proliferation. Also known as T cell growth factor
Interleukin 2
Enhance motility and promote migration of many types of white blood cells
Chemokines
Acts as a control to help down-regulate the inflammatory response when no longer needed
Transforming growth factor
Proteins produced by virally infected cells and protect the neighboring cells
Interferon
Type of interferon that is associated with non specific immunity. Activates natural killer cells and enhanced the expression of MHC class 1 proteins, thus increasing the recognition and killing of virus infected cells
Type 1
Type 1 alpha and beta is secreted by?
Alpha-leukocytes
Beta-fibroblasts
Type of interferon that is associated with specific immunity
Type 2
IFN gamma is secreted by?
T cells
Released by platelet during coagulation. Action against gram positive bacteria
Beta lysin
Chemical name of beta lysin
3,6-diaminohexanoic acid
Increases cytolytic ability of natural killer cells. It also serves as an important link between the innate and adaptive immune responses by enhancing defenses against intracellular pathogens
Interleukin 12
Enhances the immune response in a number of key ways
IFN gamma
Enhanced activity of:
Cytotoxic T cells
Natural killer cells
Antigen presentation
T helper Cell 1 (Th1)
Enhanced activity of: Antibody formation Allergic response Antiparasite response Antigen presentation
Th2 cell
Establishment of peripheral tolerance inhibition of:
Th1 cells
Th2 cells
Antigen presenting cells
Treg cells
Antibody responsible for immunoregulation
IgD
A substance that coats particle and makes them more susceptible to phagocytes
Opsonin