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Therapeutics Exam 2 > HIV > Flashcards

HIV Flashcards

0
Q

Complera

A

FTC
RPV
TDF

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1
Q

Trizivir

A

ABC
ZDV
3TC

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2
Q

Epzicom

A

ABC

3TC

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3
Q

Combivir

A

3TC

ZDV

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4
Q

What tests do you need to run for certain HIV drugs?

A

Abacavir- HLA-B5701

MVC - tropism test

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5
Q

List NRTIs

A 
ABC
ddI
FTC
3TC
d4T
TDF
ZDV
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6
Q

List NNRTIs

A

EFV
NVP
RPV

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7
Q

List PIs

A 
ATV
DRV
FPV
LPV/r
RTV
TPV
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8
Q

What are the 6 classes of HIV meds?

A 
NRTIs
NNRTIs
PIs
Integrase Inhibitors
Fusion Inhibitors
Chemokine Receptor Antagonists
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9
Q

Most common mode of HIV transmission

A

Sexual

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10
Q

Strongest risk predictor for perinatal transmission of HIV

A

High maternal viral load

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11
Q

Strategies to reduce perinatal HIV transmission

A

No breastfeeding
C-section
Decrease mother viral load
ZDV antepartum, postpartum and intrapartum

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12
Q

CCR5 occurs mainly on the surface of

A

Memory CD+4 cells and macrophages

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13
Q

A pt that is ____ for a genetic defect in ____ gene may be protected from HIV infection

A

Homozygous

CCR5

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14
Q

CXCR4 receptors occur mainly…

A

On the surface of both naïve and memory CD4+ T cells

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15
Q

Retroviral DNA enters the host genome via the enzyme…

A

Integrase

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16
Q

Strains of HIV that affect CD4+ more than macrophages are known as:

A

T-tropic

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17
Q

Strains of HIV that affect macrophages more than CD4+ cells are known as:

A

M-tropic

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18
Q

Two NRTIs that affect the liver

A

ABC and ZDV

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19
Q

List Integrase Inhibitors

A

DTG - new
EVG
RAL

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20
Q

List Fusion Inhibitors

A

T20 (Fuzion-enfuvirtide)

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21
Q

List CCR5 Antagonists

A

MVC

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22
Q

What drug is CI at CrCl < 70?

A

EVG (Stribild)

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23
Q

Stribild

A

EVG
cobi
TDF
FTC

24
Q

Truvada

A

TDF

FTC

25
Q

Atripla

A

TDF
EFV
FTC

26
Q

PIs are met by…

A

Liver

27
Q

NRTIs are met by…

A

Renally except ABC and ZDV

28
Q

NNRTIs are met by…

A

Liver

29
Q

You can test drug levels with…

A

PIs

30
Q

____ should be taken WITH FOOD

A 
All PIs except TPV and LPV/r tablet...
LPV/r oral solution
RTV
ATV
DRV
31
Q

Brand name of PI only supplied as a combo…

A

Kaletra

LPV/r

32
Q

Dosing interval for PIs are all available ____, except for ____.

A

Daily

Except for tipranavir (TPV) which is BID

33
Q

Drug that can cause false-positive on cannabinoid and BZD drug screen

A

EFV

in Atripla

34
Q

CCR5 Antagonists are met by…

A

Liver

35
Q

What does a mixed tropism test tell you?

A

Cannot use MVC

36
Q

HIV should be diagnosed by…

A

Rapid HIV test or ELISA

37
Q

Two things to watch with HIV pt…

A

Viral load

CD4+ count

38
Q

Factors associated with poor CD4+ response…

A

CD4+ <200
Older age
Coinfections (hep C, leukemia, HIV 2, etc.)
Medications (both ARVs-ZDV,TNF,ddI + other meds)
Persistent immune activation
Loss regeneration potential of the immune system

39
Q

How often do you assess viral load and CD4+?

A

Once stable q3-6 mo.

Once CD4+ stable for 2 yrs, can assess annually

40
Q

Indications for plasma HIV RNA testing

A 
Initial eval of newly diagnosed pt
Prior to initiation of therapy
2-8 weeks after start of therapy
Q3-4 mos after stable and on therapy
Clinical event or significant decline in CD4+ cells
41
Q

What type of testing is done on pt with HIV infection when they enter care regardless of whether therapy will be initiated immediately

A

Genotypic assay - examines genetic components of virus (examine viral DNA)

42
Q

Indications for HLA-B 5791 testing

A

ABC
Trizivir
Epzicom

43
Q

HAART Therapy

A
  1. Always consist of a NRTI backbone (2 drugs)

2. Always consists of either a NNRTI or PI or Integrase Inhibitor

44
Q

FTC

A

Emtricitabine (NRTI)

45
Q

Baby

A

ZDV

46
Q

When to worry about PCP

A

CD4+ < 200

47
Q

When to worry about toxo

A

CD4+ < 100

48
Q

When to worry about MAC

A

CD4+ < 50

49
Q

When to worry about strep pneumoniae

A

If no pneumo Vax

50
Q

When to worry about influenza A & B

A

All HIV pts

51
Q

When to worry about histo

A

Location (AR)

CD4+ < 150

52
Q

OI PCP tx

A

Bactrim

alt-dapsone, aerosolized pentamidine, atovaquone

53
Q

OI Toxo tx

A

Bactrim

alt.- dapsone

54
Q

OI MAC tx

A

Azithromycin
Clarithromycin
alt. rifabutin (watch drug intx)

55
Q

OI Influenza A & B tx

A

INACTIVATED influenza vax

56
Q

OI Histo tx

A

Itraconazole

(Ampho B in acute tx)

57
Q

OI Aspergillosis tx

A

Voriconazole

alt- Ampho B

Therapeutics Exam 2 (15 decks)

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