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Therapeutics Exam 2 > HIV > Flashcards

HIV Flashcards

0
Q

Complera

A

FTC
RPV
TDF

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1
Q

Trizivir

A

ABC
ZDV
3TC

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2
Q

Epzicom

A

ABC

3TC

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3
Q

Combivir

A

3TC

ZDV

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4
Q

What tests do you need to run for certain HIV drugs?

A

Abacavir- HLA-B5701

MVC - tropism test

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5
Q

List NRTIs

A 
ABC
ddI
FTC
3TC
d4T
TDF
ZDV
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6
Q

List NNRTIs

A

EFV
NVP
RPV

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7
Q

List PIs

A 
ATV
DRV
FPV
LPV/r
RTV
TPV
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8
Q

What are the 6 classes of HIV meds?

A 
NRTIs
NNRTIs
PIs
Integrase Inhibitors
Fusion Inhibitors
Chemokine Receptor Antagonists
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9
Q

Most common mode of HIV transmission

A

Sexual

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10
Q

Strongest risk predictor for perinatal transmission of HIV

A

High maternal viral load

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11
Q

Strategies to reduce perinatal HIV transmission

A

No breastfeeding
C-section
Decrease mother viral load
ZDV antepartum, postpartum and intrapartum

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12
Q

CCR5 occurs mainly on the surface of

A

Memory CD+4 cells and macrophages

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13
Q

A pt that is ____ for a genetic defect in ____ gene may be protected from HIV infection

A

Homozygous

CCR5

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14
Q

CXCR4 receptors occur mainly…

A

On the surface of both naïve and memory CD4+ T cells

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15
Q

Retroviral DNA enters the host genome via the enzyme…

A

Integrase

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16
Q

Strains of HIV that affect CD4+ more than macrophages are known as:

A

T-tropic

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17
Q

Strains of HIV that affect macrophages more than CD4+ cells are known as:

A

M-tropic

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18
Q

Two NRTIs that affect the liver

A

ABC and ZDV

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19
Q

List Integrase Inhibitors

A

DTG - new
EVG
RAL

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20
Q

List Fusion Inhibitors

A

T20 (Fuzion-enfuvirtide)

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21
Q

List CCR5 Antagonists

A

MVC

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22
Q

What drug is CI at CrCl < 70?

A

EVG (Stribild)

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23
Q

Stribild

A

EVG
cobi
TDF
FTC

24
Truvada
TDF | FTC
25
Atripla
TDF EFV FTC
26
PIs are met by...
Liver
27
NRTIs are met by...
Renally except ABC and ZDV
28
NNRTIs are met by...
Liver
29
You can test drug levels with...
PIs
30
____ should be taken WITH FOOD
``` All PIs except TPV and LPV/r tablet... LPV/r oral solution RTV ATV DRV ```
31
Brand name of PI only supplied as a combo...
Kaletra | LPV/r
32
Dosing interval for PIs are all available ____, except for ____.
Daily | Except for tipranavir (TPV) which is BID
33
Drug that can cause false-positive on cannabinoid and BZD drug screen
EFV | in Atripla
34
CCR5 Antagonists are met by...
Liver
35
What does a mixed tropism test tell you?
Cannot use MVC
36
HIV should be diagnosed by...
Rapid HIV test or ELISA
37
Two things to watch with HIV pt...
Viral load | CD4+ count
38
Factors associated with poor CD4+ response...
CD4+ <200 Older age Coinfections (hep C, leukemia, HIV 2, etc.) Medications (both ARVs-ZDV,TNF,ddI + other meds) Persistent immune activation Loss regeneration potential of the immune system
39
How often do you assess viral load and CD4+?
Once stable q3-6 mo. | Once CD4+ stable for 2 yrs, can assess annually
40
Indications for plasma HIV RNA testing
``` Initial eval of newly diagnosed pt Prior to initiation of therapy 2-8 weeks after start of therapy Q3-4 mos after stable and on therapy Clinical event or significant decline in CD4+ cells ```
41
What type of testing is done on pt with HIV infection when they enter care regardless of whether therapy will be initiated immediately
Genotypic assay - examines genetic components of virus (examine viral DNA)
42
Indications for HLA-B 5791 testing
ABC Trizivir Epzicom
43
HAART Therapy
1. Always consist of a NRTI backbone (2 drugs) | 2. Always consists of either a NNRTI or PI or Integrase Inhibitor
44
FTC
Emtricitabine (NRTI)
45
Baby
ZDV
46
When to worry about PCP
CD4+ < 200
47
When to worry about toxo
CD4+ < 100
48
When to worry about MAC
CD4+ < 50
49
When to worry about strep pneumoniae
If no pneumo Vax
50
When to worry about influenza A & B
All HIV pts
51
When to worry about histo
Location (AR) | CD4+ < 150
52
OI PCP tx
Bactrim | alt-dapsone, aerosolized pentamidine, atovaquone
53
OI Toxo tx
Bactrim | alt.- dapsone
54
OI MAC tx
Azithromycin Clarithromycin alt. rifabutin (watch drug intx)
55
OI Influenza A & B tx
INACTIVATED influenza vax
56
OI Histo tx
Itraconazole | (Ampho B in acute tx)
57
OI Aspergillosis tx
Voriconazole | alt- Ampho B

Therapeutics Exam 2 (15 decks)

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