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NAPLEX > HIV > Flashcards

HIV Flashcards

1
Q

efavirenz/TDF/emtricitabine

A

Atripla

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2
Q

bictegravir/emtricitabine/TAF

A

Biktarvy

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3
Q

rilpivirine/TDF/emtricitabine

A

Complera

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4
Q

doravirine/TDF/lamivudine

A

Delstrigo

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5
Q

dolutegravir/lamivudine

A

Dovato

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6
Q

elvitegravir/cobicistat/TAF/emtricitabine

A

Genvoya

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7
Q

dolutegravir/rilpivirine

A

Juluca

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8
Q

rilpivirine/emtricitabine/TAF

A

Odefsey

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9
Q

elvitegravir/cobicistat/TDF/emtricitabine

A

Stribild

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10
Q

efavirenz/TDF/lamivudine

A

Symfi, Symfi Lo

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11
Q

darunavir/cobicistat/TAF/emtricitabine

A

Symtuza

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12
Q

dolutegravir/abacavir/lamivudine

A

Triumeq

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13
Q

lamivudine/TDF

A

Cimduo

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14
Q

zidovudine/lamivudine

A

Combivir

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15
Q

TAF/emtricitabine

A

Descovy

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16
Q

emtricitabine

A

Emtriva

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17
Q

lamivudine

A

Epivir

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18
Q

abacavir/lamivudine

A

Epzicom

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19
Q

zidovudine

A

Retrovir

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20
Q

TDF/emtricitabine

A

Truvada

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21
Q

TDF

A

Viread

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22
Q

abacavir

A

Ziagen

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23
Q

raltegravir

A

Isentress, Isentress HD

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24
Q

dolutegravir

A

Tivicay

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25
Q

rilpivirine

A

Edurant

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26
Q

etravirine

A

Intelence

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27
Q

doravirine

A

Pifeltro

28
Q

efavirenz

A

Sustiva

29
Q

nevirapine

A

Viramune, Viramune XR

30
Q

maraviroc

A

Selzentry

31
Q

enfuvirtide

A

Fuzeon

32
Q

ibalizumab-uiyk

A

Trogarzo

33
Q

ritonavir

A

Norvir

34
Q

darunavir

A

Prezista

35
Q

atazanavir

A

Reyataz

36
Q

A phlebotomist had an accidental needlestick injury while drawing a blood sample from an HIV-positive patient. Which drug combo is the preferred regimen for PEP?

A

raltegravir + TDF + emtricitabine

37
Q

KD is 35 y/o female with no known PMH. She is married to an HIV-positive man. She has received a Rx for pre-exposure prophylaxis. Which labs must be performed before beginning therapy?

A

HIV Ab test, hepatitis B, STDs

38
Q

Which antiretroviral drug is available as an IV formulation that is used to prevent perinatal transmission of HIV?

A

zidovudine

39
Q

Which medication requires screening to determine HIV tropism before starting treatment?

A

maraviroc (only effective in CCR5-tropic disease)

40
Q

The pharmacist should contact the medical provider about which of the following interaction(s)?

A

simvastatin and ritonavir; Prezista and simvastatin

41
Q

What are the recommended first-line treatments for a patient with newly diagnosed HIV?

A

Dovato

42
Q

What are the recommended first-line treatments for a patient with newly diagnosed HIV?

A

Biktarvy, Triumeq, Dovato

43
Q

EM has been on ART for 3 years and has been adherent. His doctor recently noticed some s/e from the medicines he is taking. EM is experiencing dyslipidemia, an abnormal fat deposit at the base of his neck and high blood sugar. These s/e most commonly occur with the following class of medications:

A

Protease inhibitors

44
Q

Which ARTs could cause an allergic rxn in a patient with a sulfa allergy?

A

darunavir, fosamprenavir, tipranavir

45
Q

Stribild is contraindicated in which of the following conditions?

A

CrCl< 50 mL/min. Stribild contains TDF, which is nephrotoxic. It should be discontinued when the CrCl <50 mL/min. Do not start treatment if the CrCl <70 mL/min.

46
Q

How should efavirenz be administered to decrease CNS effects?

A

at bedtime on an empty stomach

47
Q

Testing for the HLA-B*5701 allele is required before prescribing which medication?

A

abacavir

48
Q

KD is a 35-year-old female who is HIV-negative and is married to an HIV-positive man. She is interested in a medication that will decrease her chances of contracting HIV. Which of the following is an appropriate recommendation?

A

emtricitabine + TDF (Truvada)

Indicated as PrEP for women.

49
Q

Which of the following ARTs is given via SQ injection?

A

enfuvirtide

50
Q

Which antiretroviral class should be given separately from antacids?

A

Integrase strand transfer inhibitors. Take 2 hours before or 6 hours after cation-containing products, including antacids.

51
Q

LA is a 31-year old female who started ART 2 months ago when she was found to be HIV-positive. She now presents with s/s of immune reconstitution inflammatory syndrome (IRIS). What is an appropriate course of action?

A

Continue her current ART.

*Treatment of IRIS includes treating the underlying pathogen, continuing ART and, in select cases, the addition of corticosteroids to ART.

52
Q

The initial evaluation for a new HIV diagnosis should include testing for which of the following?

A

CD4 count, HIV viral load, drug resistance genotypic testing, CMP, hepatitis B and C testing, pregnancy testing (in women)

53
Q

Which of the following is a significant side effect of zidovudine?

A

anemia

54
Q

What is the minimum amount of time that a patient should wait after an HIV exposure before using the OraQuick In-Home HIV test?

A

3 months (testing sooner can lead to a false-negative result)

55
Q

A healthcare worker has started PEP therapy for a needlestick injury. How long should the treatment be continued?

A

28 days (4 weeks)

56
Q

PS is a 65-year old male who has been HIV positive for 20 years. He complains that for the past 6 months he has not had an appetite and has lost significant muscle mass. Which of the following drugs could be recommended to address PS’s concerns?

A

nabilone, Megace ES, dronabinol

PS is likely experiencing HIV Wasting Syndrome. These meds can help to increase appetite.

57
Q

Which of the following is a major benefit of TAF when compared to TDF?

A

Lower risk of nephrotoxicity. However, both formulations are nephrotoxic and require renal dose adjustment.

58
Q

A 39-year-old-female presents to the pharmacy reporting that her OraQuick test was positive. What should the pharmacist recommend as the next step?

A

Refer to follow-up testing to confirm the diagnosis

59
Q

Cobicistat is used in ART regimens as a/an:

A

PK booster (CYP450 3A4 inhibitor)

60
Q

What are warnings associated with all NRTIs?

A

lactic acidosis, hepatomegaly with steatosis

61
Q

For ART to be effective long-term, the adherence rate must be at least…

A

95% (meaning patient cannot miss more than one dose/month)

62
Q

CS is a 37-year-old female presenting to the HIV clinic for a routine appointment. During the physical exam, it is noted that her skin and sclera appear yellow. Which medication is she likely receiving that is causing this side effect?

A

atazanavir (aka “bananavir”)

63
Q

Which medication has a boxed warning due to a risk of serious hypersensitivity reactions?

A

abacavir (do not rechallenge if the patient experiences a reaction)

64
Q

Which risks are associated with didanosine?

A

Pancreatitis, severe hepatomegaly, peripheral neuropathy

65
Q

All NNRTIs are associated with…? hint: end in -ine, except efavirenz

A

BBW: hepatoxicity, rash (including SJS/TENS)

66
Q

Rilpivirine is associated with what side effects?

A

depression, mood changes, insomnia, QT prolongation, serious skin reactions, DRESS

NAPLEX (25 decks)

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