Histoplasmosis Flashcards
Where is histoplasma capsulatum found?
America
Asia
Southern Africa
Where is histoplasma duboisii found?
Central Africa
West Africa
What is the reservoir for histoplasma?
Bat guano
Nitrite enriched soil (bird droppings)
What are the features of African histoplasmosis?
Skin/subcutaneous lesions
Bone involvement
What is the appearance of histoplasma in the mould phase?
Tuberculate macroconidia
What is the appearance of histoplasma in the yeast phase?
Narrow-based budding yeasts
How is histoplasma disseminated haematogenously?
Inside macrophages
How can you identify histoplasma on microscopy?
Narrow-based intracellular budding yeasts
Artificial capsule
Vacuole appearance in cytoplasm
Which diseases does histoplasma mimic microscopically?
C. glabrata
Talaromyces marneffei
Emergomyces
Leishmania donovanii
Toxoplasma gondii
How can you diagnose histoplasmosis?
- Microscopy
- Culture
- Antigen detection
Which is greater in progressive disseminated histoplasmosis: Ag or Ab?
Ag > Ab
Which is greater in chronic pulmonary histoplasmosis: Ag or Ab?
Ab > Ag
In which disease forms does antigen detection of histoplasmosis perform best?
Chronic pulmonary
Progressive disseminated
In which disease form does serology for histoplasmosis work perform best?
Subacute pulmonary
What are the definite indications of histoplasmosis treatment?
Acute diffuse pulmonary infection with moderate-severe symptoms
Chronic cavitatory pulmonary infection
Disseminated
CNS
