Histoplasmosis Flashcards

1
Q

Clinica

A

Perdida ponderal, fiebre, escalofrios, hipotension, hepatoesplenomegalia, lesiones en piel y membranas mucosas, pancitopenia, infiltrados pulmonares difusos, CID e insuficiencia respiratoria aguda. Ulceras mucocutaneas, insuficiencia suprarrenal,

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2
Q

Paraclinicos

A

aumento de la VSG y en la FA , pancitopeia e infiltrados reticulo nodulaes difusos

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3
Q

Dx

A

Cultivo tara 6 semanas, puede emplearse biopsia con tincion PAS o metanamina argentica

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4
Q

P incubacion

A

5-18 dias

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5
Q

Etiologia

A

Hongo dimorfico que presenta microconidios en la forma filamentosa y microconidias forma infectante
Hongo intracelular.

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6
Q

Tambien es conocida como

A

Enfermedad de Daring, histoplasmosis clasica, enfermed d las cavernas, del valle de ohio y reticuloendoteliosis

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7
Q

Transmision

A

Excretas de aves o murcieagos

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8
Q

Epidemioogia

A

Norteamerica, centroamerica en EUA, mx Tabasco, campeche, chiapas, guerrero veracruz, oaxaca, nuevo leon y tamaulipas.

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9
Q

Tratamiento

A

Formas graves Anfotericina B se puede emplear metilprednisolna antifungico de eleccion para forms leves es itraconazol

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10
Q

Terapia de mantenimiento

A

Itraconazol 200 mg VO curante 3 dias por 12 meses

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11
Q

Tiene predominio de afectar

A

Sistema reticuloendotelial

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12
Q

Forma infecciosa de esta enfermedad

A

Microconidias, es un hongo dimorfico su forma filamentosa es la macroconidia, desarrollan en el medio intracelular

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13
Q

Forma patogena

A

Levaduriforme ( macroconidias)

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14
Q

Principal reservorio del patogenos

A

Excretas de murcielagos, algunas aves

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15
Q

Tratamiento

A

Elecciòn itraconazol si pone en riesgo tu vida usar Anfotericina B ( ketoconazol coo segunda linea)
Metilpredinosolona si hay dificultad respiratoria

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