Histology and Embryology Flashcards
Preimplantation Period
first week of conception
Embryonic Period
weeks 2 to 8
Fetal Period
weeks 9 to birth
Fertilization Stage
Preimplantation
formation of zygote
zygote receives 23 chromosomes from mom and 23 from dad
zygote undergoes mitosis and eventually becomes a blastocyst
Implantation
Preimplantation Period
by 7 days, the blastocyst will be endometrium
after one week, it will consist of a trophoblast layer (nutritive) and a embroblast layer (becomes embryo)
Bilaminar Disk
Embryonic Period
consists of a superior epiblast layer and an inferior hypoblast layer
disc is suspended between 2 spaces - the amniotic cavity and the yolk sac
Trilaminar Disk
Embryonic Period
Consists of Mesenchyme, Ectoderm, Mesoderm, Endoderm
Mesenchyme Layer
differentiates into different connective tissue
(odontoblasts, osteoblast, fibroblast ect)
Ectoderm
forms the epithelial enamel organ
(week 3 of embryonic period)
Mesoderm
forms during embryonic period
forms the dental papillae which differentiates into dental pulp and elaborates the dentin
called the dental sac
forms the cementum covering the root and periodontal membranes
Endoderm
forms during embryonic period
forms epithelial linings of the respiratory passages and digestive tract
Embryonic Folding
Last stage of Embryonic Period (end of week 9)
most organs and body systems are developed
most congenital malformation occurs in this stage
enlargement of embryo into a fetus
Period of Face Development
Weeks 3-12
First Brachial Arch
AKA Mandibular Arch
Divides into maxillary and mandibular processes
Mandibular Process
Lower parts of the face and lower lip
anterior ⅔’s of the tongue
What forms the posterior ⅓rd of the tongue and the hyoid bone?
Second and third brachial arches
Maxillary Process
Lateral palatine processes
upper parts of cheek
sides of upper lip (not philtrum)
Frontal Process
forhead and frontal bone
Median Nasal Process
Center and tip of nose
nasal septum
globular process (philtrum, premaxillary palate (anterior) )
Lateral Nasal Process
sides of nose
infraorbital area
Stomodeum
primitive mouth
lined by ectoderm, which will become oral epithelium
mesoderm differentiates into ectomesenchyme
Week 3
Period of Tongue Formation
Develops weeks 4 to 8
Filiform Papillae
- *only papillae with no taste buds**
- keratinized*
elongation known as hairy tongue
Fungiform Papillae
Few, large red bumps
contain taste buds
Foliate Papillae
folds of tissue at posterior, lateral boarder
contain taste buds
Circumvallate Papillae
8-12 in number
anterior to the sulcus terminalis
contains taste buds and glands of Von Ebner
Tongue Innervation
Hypoglossal: motor nerve
Trigeminal V3: sensory to anterior ⅔
Facial: taste to anterior ⅔ (via chorda tympani)
Glossopharyngeal: taste and sensory posterior ⅓
Extrinsic Muscles of the Tongue
hypoglossus ⇒ below
styloglossus ⇒ back
genioglossus ⇒ stick out tongue
palatoglossus ⇒ above tongue, prevents choking
Period of Palatal Formation
Weeks 6 to 12
Hard Palate Formation
Primary Palate (premaxilla) ⇒ anterior ⅓
Secondary Palate (formed from 2 palatal shelves) ⇒ posterior ⅔
NOTE: if 2 palatal shelves dont fuse, causes cleft palate
Initiation Stage
(AKA Induction)
WEEKS 6-7
ectoderm gives rise to oral epithelium and dentinal lamina
Enamel is forming
Bud Stage
(AKA Proliferation)
WEEK 8
dental lamina grows into mesenchymal (connective) tissue at 20 places to form primary teeth
enamel grows into dentin and pulp
Cap Stage
WEEKS 9-10
- enamel organ develops from dental lamina to produce enamel
- Dental Papilla arises from specialized tissue to produce dentin and pulp
- Dental Sac surrounds tooth and becomes PDL, alveolar bone, and cementum
PAC the SAC in CAP (PDL, alveolar bone, cementum from the dental sac)
Bell Stage
WEEKS 11-12
Enamel Organ forms 4 layers
- Outer Enamel Epithelium (forms hertwigs epithelial root sheath)
- Stellate Reticulum
- stratum intermedium
- Inner Enamel Epithelium (becomes ameloblasts)
DEJ develops from basement membrane
- odontoblasts formed
Root Formation
occurs after the crown is complete and ends 1-4 years after eruption
Apposition Stage
enamel, dentin, cementum are secreted in increments
Dentinogenesis: process of dentin matrix formation
Amelogenesis; process of enamel matrix formation
Maturation Stage
dental tissues develop into their mature tissues and undergo calcification by deposition of hydroxyapatite crystals
Hertwigs Epithelial Root Sheath
(HERS)
Develops from IEE and *OEE
dissolves after root formation
Has the potential to form cysts if remnants remain
Cleft Palate
Failure of palatal shelves to fuse with each other
causes malpositioning of teeth and mouth breathing
weeks 8-12
obturator is used to correct and fuse palate
Cleft Lip
Failure of fusion between maxillary process and median nasal process
weeks 4-7
usually unilateral
increases risk of oral infection, periodontal disease, caries, and malnutrition
Enamel Composition and Origin
96% inorganic material
Ectoderm
Lines of Retzius
dark incremental lines from mineralization on enamel
Outer Enamel Organ
outlines the shape of enamel
Inner Enamel Epithelium
*develops ameloblasts on concave side of enamel organ
Stratum Intermedium
layer above IEE
Enamel Spindles
ends of odontoblastic processes which cross the DEJ
Hunter-Schreger Bands
light or dark bands of enamel perpendicular to DEJ
caused by curvature of enamel rods
Perikymata
lines on enamel surface where lines of Retzius end
Enamel Tufts
hypomineralization of enamel rods near DEJ
Dentin Composition and Origin
70% inorganic material
Mesenchyme
T/F Dentin Stays Vital Throughout the Life of a Tooth?
True
Lines of Von Ebner
incremental dentinal lines of daily growth
Tomes Granular Layer
outer portion of dentin beneath root cementum adjacent to DCJ
Peritubular Dentin
dentin that formed immediately around odontoblastic process
more mineralized than other parts of dentin
Intratubular Dentin
Less mineralized remaining dentin in between tubules
Mantle Dentin
first layer of dentin next to the DEJ
Circumpolar Dentin
layer of dentin around pulpal wall
Production of Dentin
Produced by odontoblasts from dental papilla
Primary Dentin
Deposited before completion of the root
Secondary Dentin
Develops after tooth is in occlusion
Developed by odontoblasts in pulp
Tertiary Dentin
formed in response to trauma
Sclerotic Dentin
fully calcified dentin associated with chronic injury
Cementum Formation
50% mineralized
produced by cementoblasts in PDL
What nourishes cementum?
PDL
Acellular vs Cellular Cementum
Acellular: found at CEJ (more coronal) THINNEST
Cellular: found at apex (more apical) THICKEST
Where does is the root derived from?
cervical portion of enamel organ
IEE and OEE fuse together to elongate after crowns are formed
T/F the root is fully formed when the crown erupts
False
Importance of Pulp
vital, sensory, and responsive portion of the tooth
What is Contained in Pulp?
blood vessles
nerve fibers
fibroblasts
odontoblasts
histocytes
pulp stones