histology

Question 1

Whats the characteristics of Squamous cell carcinomas?

Answer 1

Keratin production and intercellular bridge-
But carcinomas are always NOT keratinising (oesophagus, vagina?)

SSC-use keratin as clue, but intracellular is more specific

Question 2

what are the main histological Characteristics of Adenocarcinomas?

Answer 2

base: Mucin productions and forming glands (crypts/around an empty space)
but can be in so many part of the body-and they have extra features depending on origin (breast, stomach, pit gland etc)

Question 3

Where do you get mainly SSC?

Answer 3

Skin, head and neck, oesophagus, anus, cervix, vagina

Question 4

Where do you get adenocarcinomas

Answer 4

Lung, breast, pancreas, etc

Question 5

histology Characteristics of melanoma?

Answer 5

Expect lots of melanin/pigment-pigments in all the cells around the tumour (not just tumour)

Question 6

What are some used stains for histology?

Answer 6

Iron staining-useful

Amyloid stain (in glomerulus)-congo red
apple green Birefringent-go green

Immonohistological-AB’s that bind target, then AB that bind the first AB with a tag
e.g.: cytokeratin marker (epithelial cells)
CD45 marker (lymphoid marler)
Herpes simplex markers