histo renal Flashcards
kawasaki disease sx
strawberry tongue/ mouth inflammation cervical LN fever >5 days hand s and sole desquamation conjunctivitis
who gets kawasaki disease
<5yo
complication of kawasaki disease
coronary artery aneurysm
who gets buergers disease
men <35yo who smoke
pathology of Buerger’s disease
inflammation of arteries supplying the extremities e.g. radial and tibial- occlusion
appearance of Buerger’s disease on angiography
corkscrew due to segmental occlusive lesions
what is the triad of wegeners granulomatosis
saddle nose pulmonary haemmorhage cresenteric glomerulonephritis
what are nasal sx of wegeners
epistaxis sinusitis saddle nose
what are the pulmonary symptoms of wegeners
cavitations pulmonary haemmorhage
what are the renal symptoms of wegeners
crescenteric glomerulonephritis
triad of churg strauss
eosinophilia asthma vasculitis
what autoantibody mediates churg strauss
p ANCA against MPO
symptoms of microscopic polyangitis
pulmonary haemmorhage withglomerulonephritis
autoantibody in microscopic polyangiits
pANCA against MPO
what antibody mediates henoch scheinlich purpura
IgA
what are the symptoms of Henoch scheinlich purpura
UTI that after 5 days is followed by a purpuric rash over lower limb extensors and buttocks glomerulonephritis colicky abdo pain arthritis orchiditis
autoantibody for wegeners
c ANCA against PR3
what renal diseases affect the glomerulus
nephrotic syndrome nephritic syndrome
what renal diseases affect the tubules and interstitium
acute tubular necrosis tubulointerstitial nephritis
what are the three subtypes of tubulointerstitial nephritis
acute pyelonephritis chronic pyelonephritis with reflux nephropathy interstitial nephritis
what renal disease affect the renla blood vessels
haemolytic uraemic sndrome thrombotic thrombocytopenic purpura
triad of nephrotic syndrome
proteinuria (>3g/24hrs) hypoalbuminaemia oedema (+hyperlipidaemia)
buzzwords for nephrotic syndrome
frothy urine facial oedema in kids peripheral oedema in adults
minimal change disease
primary cause of nephrotic syndrome paediatric condition
what is seen on light microscopy and electron microscopy of minimal change disease
no change on light microscopy loss of podocyte foot process on electron microscopy no immune deposits
treatment of minimal change disease
steroids very good prognosis
membrnous glomerular disease findings on light microscopy
diffuse glomerular basement membrane thickening
membranous glomerular disease findings on electron microscopy
loss of podocyte foot processes spikey subepithelial depositis
immunoflourescance findings on membranous glomerular disease
ig and complement in granular deposits along ENTIRE GBM
causes of membranous glomerular disease
SLE drugs malignancy
prognosis of membranous glomerular disease
pooor response to steroids 45% have ESRF after 2-20 years
causes of glomerulosclerosis
being afrocarribean HIV nephropathy secondary to obesity
findings on light microscopy in glomerulosclerosis
scarring and consolidation in ofcal areas of glomerulus hyalinosis
findings on electron microscopy in glomerulosclerosis
loss of podocyte foot processes
immunoflourescance findings in glomerulosclerosis
Ig and complement in scarred areas
prognosis in glomerulosclerosis
50% ESRF 50% respond to steroids
renal histological findings in diabetes
diffuse GBM thickening kimmenstial wilson nodules
what are kimmenstial wilson nodules
mesangial matrix nodules
pathology of kimmenstial wilson nodules
Nodules of pink hyaline material form in regions of glomerular capillary loops in the glomerulus. This is due to a marked increase in mesangial matrix from damage as a result of non-enzymatic glycosylation of proteins
definition of nephritic syndrome
inflammation of the glomerulus
buzzword for nephritic syndrome
coca cola urine
signs of nephritic syndrome
haematuria dysmorphic rbc/ rbc casts inurine proteinuria but not in nephrotic range raised urea and creatinine oliguria
causes of nephritic syndrome
opst infectious glomerulonephritis rapidly progessive crescenteric glomerulonephritis Buerger’s disease Alport’s syndrome beinign familial haematuria
acute post infectionous glomerulonephritis usual pathogen
group A alpha haemolytic strep strep pyogenes