histo breast Flashcards

1
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

acute mastitis pathogen

A

staph aureus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

sx of acuter mastitis

A

in lactating women erythema of breast fever pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

histological appearance of breast tissue in mastitis

A

necrotic tissue infiltrated by neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

tx of mastitis

A

abx express milk and surgical drainage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

who gets periductal mastitis

A

non-lactating women who smoke

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is seen histologically in periductal mastitis

A

keratinising squamous epithilium extending into nipple orifice

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

who gets mammary duct ectasia

A

40-60yo multip

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

pathology of mammary duct ectasia

A

large duct dilation due to granulomatous inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

sx of mammary duct ectasia

A

poorly defined periareolar mass thick white nipple secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is the pathology of fat necrosis of the breast

A

inflammatory reaction to damaged adipose tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

causes of breast fat necrosis

A

trauma Rt surgery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what causes fibroadenosis/ fibrocystic change

A

exaggerated response to hormones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is adenosis (breast)

A

increased number of acini/ lobule common in pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

cystic changes and fibrosis in fibroadenosis

A

cysts form due to lobule dilation and fill with fluid they then rupture and are calcified (fibrosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

gynacomastia definiton

A

unilateral or bilateral breast enlargment in men

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

histological appearance of gynacomastia

A

epithelial hyperplasia fingerlike projections into ducts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

fibroadenoma

A

benign overgrown of collagenous mesenchyme

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

presentation of fibroadenoma

A

spherical painless mible rubbery mass

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

duct papilloma

A

benign tumour of breast duct

21
Q

what does a duct papilloma cause

A

bloody discharge nmo lump

22
Q

what is a radial scar

A

central scar surrounded by proliferating glandular breast tissue in a stellate papttern

23
Q

RF for breast carcinoma

A

nulliparity OCP/ HRT smoking, obesity, tabacco, FH

24
Q

when does breast screening occur

A

every 3 years from 47-73 mammography

25
Q

what does mammography look for

A

calcifications or mass in the breast

26
Q

what is breast carcinoma in situ

A

neoplastic epithelial proliferation limited to ducts or lobules by the basement membrane

27
Q

what is the difference between LCIS and DCIS

A

DCIS presents with calcifications and LCIS doesn’t

28
Q

LCIS (lobar carcinoma in situ-breast)

A

incidental biopsy findings no Ecadherin no microcalifications

29
Q

what does breast DCIS put you at risk of

A

invasive breast ca

30
Q

invasive breast carcinoma subtypes

A

mucinous tubuluar ductal lobular

31
Q

invasive breast ca: mucinous

A

produce mucin which dissects into surrounding tissue

32
Q

invasive breast ca: lobular

A

cellsin single file strands

33
Q

invasive ca: tubular

A

well formed tubules with low grade nuclei <1cm

34
Q

invasive ca: ductal

A

can’t be subclassified

35
Q

what is the triple assessment

A

examination radiological exam FNA &cytology

36
Q

when is an USS used in triple assessment

A

if the woman is<35yo if older USS+ mammography

37
Q

what is checked for at biopsy in triple assessment

A

histological subtrype ER/PR receptor tubule formation mitotic activity nuclear pleomorphism

38
Q

what receptor is associated with a good prognosis in breast ca

A

ER/PR

39
Q

what receptor is asociated with poor prognosis is breast ca

A

HER2

40
Q

what medications are used for HER2 breast ca

A

herceptin trastuzumab

41
Q

how does tamoxifen work

A

mixed agonist/ antagonist of oestrogen at its receptor

42
Q

what medication is used in breast ca to reduce oestrogen

A

anastrazole

43
Q

what do basal; cell like breast ca stain positive for

A

CK5/6/14

44
Q

where do phyllodes tumours originate from

A

interlobular stroma

45
Q

what is seen on histology of phyllodes tumour

A

increased cellularity mitoses

46
Q

do phyllodes tumours metastesis

A

no

47
Q

are phyllodes tumours benign

A

usually

48
Q
A