Histo/path

Question 1

Answer 1

myeloblast

Question 2

Answer 2

band neutrophils

Question 3

Answer 3

megakaryocytes

Question 4

Answer 4

platelets

Question 5

Answer 5

aplastic anemia- look at the big fat gaps

Question 6

Answer 6

lead Pb toxicity

Question 7

Answer 7

nuclear-cytoplasmic dyssynchrony as seen in megaloblastic anemia

Question 8

Answer 8

toxic granulation.

Question 9

Answer 9

Dohle bodies as seen in may hegglin anomaly

Question 10

Answer 10

Pelger-Huet as seen in MDS

Question 11

Answer 11

left shift in WBC- increase in immature granulocytic forms

Question 12

Answer 12

leukemoid reaction- marked leukocytosis with immature granulocytes

Question 13

Answer 13

Bite cells as seen in G6PD

Question 14

Answer 14

Heinz bodies-G6PD deficiency

Question 15

Answer 15

Bite cell- see in G6PD due to the removal of Heinz bodies bodies by macrophages in the spleen

Question 16

Answer 16

iron deficiency- note the profound central pallor of the hypochromic and microcytic RBC

Question 17

Answer 17

Howell-jolly bodies- seen in sickle cell anemia with a functional hyposplenia

Question 18

Answer 18

Peripheral smear from a patient with SC disease is shown. Note the presence of target cells, polychromatophilic

Question 19

Answer 19

spherocyte- small spherical cells without central pallor as seein in thalassemia

Question 20

Answer 20

The blue stained inclusions in the RBC are oxidatively denatured precipitates of HbH

Question 21

Answer 21

Howell-Jolly bodies are red cell inclusions that are residual nuclear fragments. They may be seen in hemolysis, megaloblastic anemia, or post-splenectomy.

Question 22

Answer 22

Peripheral smear showing RBC fragmentation consistent with a microangiopathic hemolytic process

Question 23

Answer 23

Heinz bodies as seen in G6PD

Question 24

Answer 24

Giant platelet circulating in the peripheral blood of a patient with a myeloproliferative disorder

Question 25

Answer 25

Peripheral smear showing microangiopathic hemolytic features with numerous RBC fragments (helmet cells-schistocytes)- Marked thrombocytopenia is evident.

Question 26

Answer 26

ALL- lymphoblastic cells

Question 27

Answer 27

ALL reveals blasts with scant cytoplasm but prominent nucleoli

Question 28

Answer 28

ALL- some blasts have distinct nucleoli and A hand mirror cell is marked by the arrow

Question 29

Answer 29

AML- Some of the blasts have thumbprinting (arrow), which is a clue to their myeloid lineage

Question 30

Answer 30

Circulating blast with Auer rod in the blood of a patient with AML

Question 31

Answer 31

The hypergranular variety is the most common morphologic subtype of APL

Question 32

Answer 32

Follicular lymphoma- CD20 positive cells

Question 33

Answer 33

diffuse large B cell lymphoma

Question 34

Answer 34

Bone marrow aspirate from a patient with Burkitt’s lymphoma demonstrates large cells with basophilic cytoplasm containing prominent vacuoles

Question 35

Answer 35

Reed-Sternberg cell in hodgkin lymphoma

Question 36

Answer 36

nodular sclerosis involving lymph node in hodgkin lymphoma

Question 37

Answer 37

Hodgkin lymphoma mixed cellularity

Question 38

Answer 38

hodgkin lymphoma lymphocyte depletion type

Question 39

Answer 39

CLL- Peripheral smear reveals a lymphocytosis

Question 40

Answer 40

CLL smudge cells

Question 41

Answer 41

plasma cell are scattered throughout this bone marrow aspirate from a patient with multiple myeloma

Question 42

Answer 42

flaming plasma cell as seen in myeloma

Question 43

Answer 43

punched out lession as seen in myeloma

Question 44

Answer 44

CML- bone marrow aspirate us hypercellular with increased eosinophils

Question 45

Answer 45

BCR-ABL fusion of the philadelphia chromosome 9 and 22

Question 46

Answer 46

platelet clumps are noted in the peripheral blood smear of this patient with essential thrombocytopenia

Question 47

Answer 47

myelofibrosis- dacrocytes look like teardrops