HISTAMINE (H2) RECEPTOR ANTAGONISTS

Question 1

Purpose of H2-Receptor Antagonists

Answer 1

1. Suppress secretion of gastric acid
2. Alleviate symptoms of heartburn
3. Promote healing in GERD

Question 2

Should be used with caution in clients with ______ or ______

Answer 2

impaired renal or hepatic function

Question 3

Examples

Answer 3

1. Cimetidine (Tagamet)
2. Ranitidine (Zantac)
3. Famotidine (Pepcid)
4. Nizatidine (Axid)

Question 4

Cimetidine Nsg Consi
1. Can be administered __,__,__
2. Do not take with ___ (Rationale?)
3. IV can cause ____ and _____
4. _____ can decrease oral absorption
5. Cimetidine and Antacids should be administered _______
6. May cause (DADAMP)
7. Dosage should be reduced in clients with ____ (Rationale?)
8. If cimetidine is administered with WPTCL, dosage should be ____ (Rationale?)

Answer 4

1. Can be administered PO, IM, IV
2. Do not take it with food (delays drug absorption)
3. IV administration can cause hypotension and Cardiac Dysrhythmia
4. Antacids can decrease the absorption of oral cimetidine
5. Cimetidine and antacids should be administered at least 1 hour apart from each other
6. Cimetidine may cause mental confusion, agitation, psychosis, depression, anxiety, and disorientation (can cross the BBB)
7. Dosage should be reduced in clients with Renal impairment (Causes nephrotoxicity)
8. If cimetidine is administered with warfarin sodium (Coumadin), Phenytoin (Dilantin), Theophylline, or Lidocaine, the dosage of these medications should be reduced (to prevent drug interactions)

Question 5

Ranitidine
1. Can be administered same as _____
2. Side effects are ____ (Rationale?)
3. ____ by food

Answer 5

1. Can be administered (same as cimetidine)
2. Side effects are uncommon since it doesn’t cross the BBB
3. Not affected by food

Question 6

Famotidine (Pepcid) and Nizatidine (Axid)
1. Famotidine and nizatidine are similar to ____ and ____
2. These medications ______ to be administered with _____

Answer 6

1. Famotidine and nizatidine are similar to ranitidine and cimetidine
2. These medications do not need to be administered with food

Question 7

Overall Consideration for H2-Receptor Blockers
1. Take at ____ if _____ dosing is ordered
2. Avoid taking antacids for _____ before and _____ after taking this drug
3. Avoid CANA
4. Long term use leads to _____ and _____ in men and _____ in women

Answer 7

1. Take at bedtime if once-a-day dosing is ordered
2. Avoid taking antacids for 1 hour before and 1 hour after taking this drug
3. Avoid cigarette smoking, alcohol, aspirin, NSAIDs
4. Long-term use leads to gynecomastia and impotence in men and breast tenderness in women

Question 8

Adverse Effects (DRaCoFam)

Answer 8

1. Diarrhea
2. Rash and Bruising
3. Confusion
4. Fatigue
5. Malaise