Highison: Small and Large Intestine Flashcards
Layers of the small intestine
mucosa submucosa muscularis externa (inner circular outer longitudinal) serosa adventitia
How long is the small intestine?
21-25 ft
Principle site of digestion of food and absorption of products of digestion
small intestine
3 “gross” aspects of the small intestine
mesentery
plicae circulares
vasa recta
Surface modifications increase the surface area of the small intestine by 400-600 times! What are three modifications that account for this increase?
- plicae circulares (2-3x)
- intestinal villi (10x)
- microvilli (20x)
Projections/folds of the mucosa of the small intestine into the lumen. Increase absorptive surface of the mucosa.
villi
Found in the lamina propria of the small intestine
crypts of Lieberkuhn
permanent spiral folds of mucosa and submucosa in distal duodenum, jejunum, and proximal ileum
plicae circulares
What kind of epithelium is the mucosa of the small intestine?
simple columnar
Surface absorptive cells, specialized for transport of substances from intestinal lumen into circulatory system
enterocytes
Enterocytes of the mucosa of the small intestine have (blank) to increase apical surface area, and (blank) to seal off the intercellular space from the intestinal lumen
microvilli; intercellular junctions
Six cell types found in the mucosa of the small intestine
- surface absorptive cells (enterocytes)
- goblet cells
- M cells
- enteroendocrine cells
- Paneth cells
- stem cells
These cells secrete mucinogen that is converted to mucous for protection
goblet cells
These are antigen presenting cells, modified enterocytes. They cover lymphatic nodules in the lamina propria.
M cells
These cells produce nearly all the same peptide hormones that they do in the stomach
enteroendocrine cells
These cells secrete lysozyme and regulate normal intestinal flora
Paneth cells
Where are Paneth cells primarily found?
in the distal ileum
These are regenerative cells that restore the epithelial cells every 5-6 days and the Paneth cells every 4 weeks
stem cells
What do antimitotic drugs do for the small intestine?
create a higher rate of cell renewal
Occupies the villi and in between the intestinal glands (Crypts of Lieberkuhn)
lamina propria