Higher Cortical Function Flashcards

1
Q

What are the inputs and output to and from the cerebral cortex - where do they come from and where do they go

A

Most inputs are from the thalamus and other cortical areas, important input is reticular formation

Outputs are to projection fibres going down to brainstem and cord, comissural fibres between lobes, associated fibres connecting nearby regions of the cortex in same hemisphere

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2
Q

Name and briefly describe the functions of the frontal lobe

A

Motor function - primary motor cortex. Damaged causes contralateral weakness

Expression of speech - left hemisphere. Broca’s area. Damage can cause expressive dysphagia

Behaviour regulation/judgement - prefrontal cortex located here. Inhibitory neurones develop to prevent abnormal, impulsive behaviours

Cognition - prefrontal cortex. Damage acuses difficulty with complex tasks

Eye movements - frontal eye fields

Continence - cortical areas for maintaining continence

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3
Q

Name and briefly describe the functions of the parietal lobe

A

Sensory - primary sensory cortex. Damage results in contralateral anaesthesia

Comprehension of speech - part of Wernicke’s area. Damage causes receptive dysphagia

Body image - acknowledgement that body exists

Awareness of external environment - acknowledgement that things exist in external enviroment. Right side damage leads to neglect

Calculating and writing

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4
Q

What structures run through the parietal and temporal lobes and why is this important if there is damage to these lobes

A

Superior optic radiation - through parietal. Leads to contralateral inferior homonymous quadrantanopia

Inferior optic radiation - through temporal. Leads to contralateral superior homonymous quadrantanopia

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5
Q

Name and briefly describe the functions of the temporal lobe

A

Hearing - primary auditory cortext on superior surface, near Wernicke’s area

Olfaction - primary olfactory cortex on inferomedial aspect

Memory - hippocampus is found within temporal lobe

Emotion - contains limbic structures like hippocampus and amygdala

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6
Q

What are the differences between the left and right hemispheres

A

Left hemisphere does sequential processing and deals with right side of body. Does language, math and logic

Right hemisphere does whole body processing and attends both halves of space. Does body image, visuospatial awareness, emotion, musical ability

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7
Q

What is hemispatial neglect

A

Where a patient ignores the left side/space -> will only focus on right side of a picture or page

Usually caused by right parietal lobe stroke

Left parietal lobe lesion will not cause neglect as right parietal deals with both halves of space so patient will not ignore any side

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8
Q

Name a syndrome that can develop if there is destruction of the corpus callosum

A

Alien hand syndrome

Where the hemispheres cannot communicate with each other so the hands do not know what the other one is doing

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9
Q

Name three structures that make up the language pathways

A

Broca’s area

Werincke’s area

Arcuate fasciculus - connects the two areas

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10
Q

Describe Broca’s area and what happens if there is damage to the area

A

Found in inferolateral frontal lobe, near the primary motor cortex that deals with mouth and pharynx

Is responsible for production of speech as a pattern generator

Damage to broca’s area result in broca’s/expressive dysphagia where the patient understands what is being said but cannot respond as they cannot form words

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11
Q

Describe wernicke’s area and what happens if there is damage to the area

A

Wernicke’s area is found at parieto-temporal junction, near the primary auditory complex

Responsible for comprehension of speech

Damage to the area causes wernicke’s/receptive dysphagai where patient cannot understand what is being said but speaks fluently

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12
Q

Describe the pathway for repeating a heard word

A

Signal sent from ear travels to primary auditory cortex

Signal then sent to wernicke’s area which processes the sound into a word

Signal from wernicke’s sent via arcuate fasciculus to broca’s area which then sends signal to primary motor cortex

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13
Q

Describe the pathway for speaking a written word

A

Signal send from visual cortex to the wernicke’s area which processes signal into words

Wernicke’s then sends a signal to broca’s area via arcuate fasciculus

Signal then send to primary motor cortex

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14
Q

Describe the pathway for speaking a thought

A

Thought arises from many regions of the cerebral cortex and then converges on to wernicke’s area

Signal then sent to broca’s area via arcuate fasciculus

Signal then sent to primary motor cortex

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15
Q

What are the different types of memory

A

Declarative/explicit - factual information. Cerebral cortex

Non-declarative/implicit - motor skills and emotion. Subcortical structures and cerebellum

Short term - stored as reverberations/echos in cortical circuits

Long term - stored in cerebral cortex, cerebellum, etc. Requires consolidation

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16
Q

What is consolidation and what factors influence it

A

Consolidation - conversion of short term memories to long term memories

Factors influencing consolidation - emotional context, rehersal, association

17
Q

What is the name of the key molecular mechanism of memory consolidation

A

Long term potentiation

18
Q

What structure helps consolidate declarative memories

A

Hippocampus - has a role as an oscillator in facilitating consolidation of memories in the cortex