HIGH YIELD Flashcards
only on palms, soles and digits?
unique feature of thick skin
thick skin contains this protein?
eleidin, clear protein rich in lipids, derived from keratohyalin
strong characteristic of thick skin?
provides a barrier to water
these sensors are found densely packed on palms and soles
Merkel cell pressure sensors
Superficial benign
fibrous histiocytoma
Typically dimples with lateral compression
Benign lesions with excellent prognosis
what is this?
Dermatofibroma
Venous Hypertension
Typically shallow with
irregular borders with yellow, fibrinous exudate overlying
the wound bed
what is this?
Venous Insufficiency Leg Ulcers
Telangiectasias of
the feet and ankles
Hemosiderosis -
brown discoloration
what is this?
Chronic Venous Disease
stages of venous skin disease?
chronic venous insufficiency
hemosiderosis
induration
telangiectasia
dry ulcer with crust
atrophy blanche
dermoscopy:ivory white areas with linear and glomerular vessels
epidermal changes
-hyperkeratosis, parakeratosis
dermal changes
-dermal fibrosis, hemosiderin laden macrophages
positive iron stain
what is this?
venous stasis dermatitis
long-standing venous hypertension
indurated inflammatory tissue that binds the skin down to the subcutaneous tissue
elongated, glomerular like
what is this?
lipodermatosclerosis
small skin vessels
-palpable purpura
diagnostic biopsy
-leukocytoclastic vasculitis with infiltration of postcapullary venules
what is this?
vasculitis
Mottled reticulated vascular pattern -Lace-like purplish pattern -Swelling of the venules due to obstruction of capillaries by small blood clots
Common skin finding
Clotting disorders
- Cryofibrinogenemia
- Calciphylaxis
what is this?
lived reticularis
AKA Calcific uremic arteriolopathy
-EKSD on dialysis
calcification of dermal and subcutaneous arterioles and capillaries
lethal disease
-six month survival 50 percent
what is this?
calciphylaxis
Chronic, painful, ulcerative skin condition
Crusted, painful, stellate, shallow ulcerations
Ulcers heal with white, atrophic, stellate scars
with telangiectasia
-atrophy blanche-healing pattern
cutaneous biopsy
tx: pain management
what is this?
Livedoid Vasculopathy
AKA: Rheumatoid vasculitis
Periungual, necrotic lesions
Can form in hand or foot
Cutaneous intimal vasculitis secondary to elevated rheumatoid factors
what is this?
Bywater’s Lesion
Most common autoimmune blistering
disorder
many eosinophils
in the blister cavity
IgG and C3 in a linear homogenous
immunofluorescence pattern at the dermoepidermal
junction
what is this?
Bullous Pemphigoid
aka hypersensitivity
vasculitis and hypersensitivity angiitis
small-vessel inflammation
Typically a drug reaction
what is this?
Leukocytoclastic
Vasculitis
Immunoglobulin A Vasculitis
in children
Classic symptoms include a rash,
abdominal pain, joint pain, edema, scrotal swelling, and bloody stools
-palpable purpura on legs
-arthralgias
-small vessel deposition of IgA elevated 70%
what is this?
Henoch-Scholein Purpura
Common, often self-limited reaction:
-Trauma, insect bites
Both children and adults
Localized form
-Nonscaly, erythematous, annular plaque on the distal extremity
Generalized form
-Numerous confluent erythematous papules and plaques on the hands, arms, buttocks and extremities
Granuloma Annulare
what is this?
atrophic brown and yellow patch
- Pretibial and medial malleolus
- Fine telangiectasia
0.3% of diabetics
Dermoscopy
- Comma-shaped vessels
- Irregular branching vessels
- Whitish areas of degenerated collagen
Biopsy 3 to 5 mm punch
Necrobiosis Lipoidica
what is this?
Acute eruption
- Dark-red, slowly growing painful papules and plaques
- Face and the extremities
- High fever
- Neutrophilic leukocytosis
Children and adults
- URI, GI infections, Chron’s, pregnancy, malignancy, drugs
- ESR >20 mm/hour
- CRP >8000
- > 70% neutrophils
Biopsy
-Dense neutrophilic infiltrate without evidence of leukocytoclastic vasculitis
-Systemic glucocorticoids
Sweet Syndrome
Acute Febrile Neutrophilic Dermatosis
what is this?
Childhood vasculitis
Cracked, red lips and strawberry tongue
Skin peeling begins under the nails at 2 weeks -Large peeling sheets progresses over several days lasting 12 days -Extremities manifestation occurs last -Indurated edema of hands and feet -Diffuse erythema of palms and soles
Kawasaki Disease
what is this?
Hematologic disorder SCD
-Triggers stroke, myocardial infarction
Disproportionate pain
Sickle Cell Disease
painful purulent progressive leg
ulcer
what is this?
Enlarging Ankle
Ulcer
