HF

Question 1

Diuretics

Answer 1

• Loop, thiazide, and K sparing are used
• 1st line of therapy
• Given for acute pe from HF
• reduces venous pressure and arterial pressure
• reduce symptoms but does not prolong survival

Question 2

ACE inhibitors “prils”

Answer 2

Action:

• Arteriolar dialtion: reduces afterload, increase renal blood flow
• Venous dilation: reduces preload
• Suppresses AL (aldosterone)
• prevents cardiac remodeling

Question 3

Angiotensin receptor Neprilysin Inhibitor (ARNI)

Answer 3

Prototype: sacubitril/valsartan (entresto)
Action: increases natriuetic pepetides and suppresses negative effects of RAAS
-Used instead of ACE
-SE: same as ARBs as it contains a “sartan”
-Have them off of ACE for 36 hours before starting a ANRI

Question 4

IN class 2- Class 4 HF patinets

Answer 4

• reduced HF ad less death and hosipatalizations

Question 5

SE in ANRI

Answer 5

Are still the same as ARBs

Question 6

BB for HF

Answer 6

• Carvedilol (coreg)
• metropolol XL ( Toprol- X
• Bisoprolol

Question 7

BB are used in combo with

Answer 7

ACE and diuretics

Question 8

Start with small doses

Answer 8

1/10 or 1/20 and doubled every 2 weeks