Direct Vasodilators

Question 1

Direct Vasodilarors

Answer 1

• Some affect arteries, some veins, and some affect both
• Preload (venous dilation) vs. Afterload (Arterial dilation)
  SE profile changes
• Lots of diff drugs can do this

Question 2

Direct vasodilator Hydralazine

Answer 2

• hydralazine ( Apresoline)
  Action: causes direct relaxation of arteriolar smooth muscle
  -Primarily used in emergencies to quicklly decrease BP. Given IV

Question 3

Direct vasodilator Hydralazine SAE:

Answer 3

• Severe hypotension

- reflex tachycardia

Question 4

Direct vasodilator : nitroprusside (Nitropress)

Answer 4

• Causes venous and arteriolar dilation
• DOC for HTN emergency
• Defined as diastolic grater than 120

Question 5

Nitroprusside route

Answer 5

IV continous infusion

• effects begin in seconds
• not used longer than 72 hours
• toxic accumulation of thiocyanate
• if increased bv occurs -> manage with furosemide