RAAS Drugs

Question 1

ACE inhibitors USES

Answer 1

STOP ANGIE!!

• Therefore, lots of benefits
• HTN, Post MI, HF, Diabetes, Diabetic Nephropathy prevention, Stroke prevention

Question 2

Action of ACE inhibitors

Answer 2

• decreases AT -> vasodilation of the efferent arteriole -> pressure in glomerulus falls -> slows progression to chronic kidney disease
• Even if BP is normal still a good recommendation for diabetics to protect the kidneys from diabetic nephropathy

Question 3

Lisonopril Zestril (prils) Action

Answer 3

• Stop Angie
• blocks conversion of angie 1 to angie 2 -> vasodialtion and decrease fluid volume
• block aldosterone
• increase bradykinin

Question 4

SE of lisinopril

Answer 4

• Dry cough, angioedema ( can occur during any time of therpay), 1st dose hypotension, increased K+
• Don’t use in pregnancy

Question 5

ARBS or Sartans Action

Answer 5

blocks receptors at AT 2 after it is formed

• potent vasodialtor
• prevents bad affects from AT2
• blocks aldosterone

Question 6

SE: of Sartasn

Answer 6

SE:

• decreased risk of cough
• 8% cross-sensitivity with ACE for angioedema
• Don’t use in preganancy

Question 7

Protoype of Sartan

Answer 7

VAlsartan

Question 8

direct renin inhibitors Action, SE, Prototype

Answer 8

-blocks the entire RAAS process
- Prototype: aliskiren (Tekurna)
SE: angioedema, cough, diarhea
- Don’t take with high fat meal
- don’t use in pregnancy

Question 9

Aldosterone receptor blockers (Action, prototype, SE )

Answer 9

Action: competes with aldosterone at receptors in the distal tubule blocking aldosterone (fluid lost, K remains).

Prototype: spironolactone (Aldactone)
Others: eplerenone (inspra)

SE: risk for hyperkalemia (high K+)

Takes up to 48 hours to work