Heterotopic Ossification

Question 1

What are the 3 phases of a bone scan

Answer 1

Phase 1 = blood flow
Phase 2 = blood pooling
Phase 3 = bony metabolism

Question 2

What lab can you use that is the earliest and least expensive method to detect HO

Answer 2

Serum alkaline phosphatase

Question 3

What 2 medications are used to stop HO

Answer 3

NSAIDs and bisphosphonates

Question 4

What is the most sensitive method to detect early HO

Answer 4

Bone scan

Question 5

Which NSAID has been used to treat early HO

Answer 5

Indomethacin

Question 6

How soon can HO be seen with bone scan

Answer 6

First 2-4 weeks after injury

Question 7

Period of greatest risk to develop HO in TBI

Answer 7

3-4 months post-injury

Question 8

3 most commonly involved joints (in order)

Answer 8

1. Hips
2. Elbows/shoulders
3. Knees

Question 9

How soon can x-rays see HO

Answer 9

3 weeks to 2 months post-injury

Question 10

HO is the formation of _______ ____________ ___________ in extra skeletal soft tissue

Answer 10

Mature lamellar bone

Question 11

When is surgical treatment for HO done

Answer 11

After HO has matured