Disorder Of Consciousness

Question 1

MOA of dextroamphetamine

Answer 1

Sympathomimetic - Promotes release of dopamine and NE and blocks reuptake of catecholamines.

Question 2

MOA of donepezil

Answer 2

Acetylchoinesterase inhibitor

Question 3

Vegetative State:
Sleep-Wake Cycle?
Purposeful behavior?
Language?
Eyes?

Answer 3

Resumption of sleep-wake cycle.
No purposeful behavior.
Verbal/auditory startle.
Patient opens eyes.

Question 4

MOA of methylphenidate (ritalin)

Answer 4

Blocks reuptake of dopamine and norepinephrine

Question 5

Coma:
Sleep-wake cycle?
Purposeful behavior?
Language?
Eyes?

Answer 5

No sleep-wake cycle
No purposeful behavior
No communication
Eyes close

Question 6

MOA of bromocriptine

Answer 6

Dopamine agonist and inhibits prolactin secretion

Question 7

What do you see on EEG in a patient in a coma

Answer 7

Lack of sleep wake cycles

Question 8

Persistent vegetative state is defined by being in vegetative state for how long?

Answer 8

> or equal to 1 month

Question 9

What is seen on EEG in a patient in a vegetative state

Answer 9

Resumption of sleep wake cycles

Question 10

What 3 main classes of drugs are used to help with recovery process of TBI

Answer 10

1. Dopamine agonists (Or dopamine reuptake inhibitors)
2. Acetylcholinesterase inhibitors
3. Antidepressants (TCAs and SSRI)

Question 11

MOA of levodopa/carbidopa

Answer 11

Dopamine agonist

Question 12

MOA of Amantadine (symmetrel)

Answer 12

Dopamine agonist

Question 13

Minimally Conscious State:
Sleep-Wake Cycle?
Purposeful Behavior?
Language?
Eyes?

Answer 13

Sleep-Wake cycles present.
Inconsistent but reproducible purposeful behavior.
Intelligible verbalization and yes/no response.
Eyes open and may track

Question 14

Permanent vegetative state is defined by being in vegetative state for how long?

Answer 14

irreversibility after 3 months of non-traumatic brain injury and 12 months following TBI