Hereditary cancer syndromes

Question 1

Breast and ovarian cancer; prostate, pancreatic, colorectal, melanoma, endometrial, gastric, biliary

Answer 1

BRCA1 and BRCA2

Question 2

Lifetime ovarian cancer risk with BRCA1

Answer 2

40%

Question 3

Lifetime breast cancer risk with BRCA1

Answer 3

57%

Question 4

Lifetime ovarian cancer risk with BRCA2

Answer 4

18%

Question 5

Lifetime breast cancer risk with BRCA2

Answer 5

57%

Question 6

Breast and ovarian cancer; colon and rectal, stomach, small intestine, and pancreatic cancers

Answer 6

Peutz-Jeghers

Question 7

Gene for Peutz-Jeghers

Answer 7

STK11

Question 8

Breast cancer; sarcomas, brain cancer, leukemias, adrenocortical cancers

Answer 8

Li-Fraumeni

Question 9

Gene for Li-Fraumeni

Answer 9

TP53

Question 10

Breast cancer; endometrial, thyroid

Answer 10

Cowden

Question 11

Gene for Cowden

Answer 11

PTEN

Question 12

Colon, endometrial, ovarian, gastric

Answer 12

HPNCC (Lynch)

Question 13

Gene for Lynch

Answer 13

MLH1, MSH2, MSH6, PMS2

Question 14

Breast cancer; colorectal, prostate, male breast, thyroid, kidney

Answer 14

Hereditary breast cancer (CHEK2)

Question 15

Breast cancer; pancreatic and prostate cancers

Answer 15

Hereditary breast cancer (PALB2)

Question 16

Breast cancer; leukemias and lymphomas

Answer 16

Ataxia-telangectasia

Question 17

Gene for ataxia-telangectasia

Answer 17

ATM

Question 18

CHEK2: type of gene

Answer 18

Tumor suppressor (interacts with p53 and repairs DNA)

Question 19

Cancer associated with BRIP1 mutation

Answer 19

Ovarian (perform risk-reducing BSO)

Question 20

Cancer associated with RAD51C mutation

Answer 20

Ovarian (perform risk-reducing BSO)

Question 21

Inheritance patter of Cowden syndrome

Answer 21

Autosomal dominant