Hepatobiliary and Pancreatic Neoplasms

Question 1

What is a benign lesion of the liver, commonly associated with young women on oral contraceptives?

Answer 1

Liver cell adenoma

Question 2

What viral disease is associated with hepatocellular carcinoma?

What are some other risk factors?

Answer 2

Hepatitis - HBV and HCV infection

Others:

• Chronic alcoholism → cirrhosis

Question 3

Morphology of HCC?

Answer 3

• Hepatomegaly
• Paler than surrounding liver
• Single or multipe areas, diffusely infiltrative

Question 4

How is HCC diagnosed

Answer 4

• Needle core biopsy
• Cytology
• Radiologically

Question 5

What is the term for malignancy of biliary epithelium?

Answer 5

Cholangiocarcinoma

Question 6

Risk factors for malignancy of biliary epithelium?

Answer 6

• PSC
• Chronic infection of biliary tree by flukes (Asia)

Question 7

Morphology of cholangiocarcinoma?

Answer 7

• Mass
• Thickening and narrowing of bile ducts
• Adenocarcinoma

Question 8

What is the most common cause of malignancy in the liver?

Answer 8

Metastasis from another site:

• GIT (portal vein brings blood from GIT straight to liver)
• Basically any others too

Question 9

Most important type of pancreatic cnacer?

Answer 9

Pancreatic Duct Adenocarcinoma (PDAC)

Question 10

Three types of benign and three malignant hepatobiliary neoplasms

Answer 10

Benign

• Haemangioma
• Hepatocellular adenoma (most common)
• Bile duct adenoma

Malignant

• Hepatocellular carcinoma
• Cholangiocarcinoma
• Hepatoblastoma

Question 11

In which demographic/risk factor is liver cell adenoma often seen?

Answer 11

Common in young women on oral contraceptives

Question 12

Complications of liver cell adenoma?

Answer 12

• Rupture
• Rare progression to HCC

Question 13

HCC treatment options (3)

Answer 13

• Resection
• Transplantation
• Chemo/Radiation