Benign and Malignant Breast Disease Flashcards

1
Q

Describe the breast screening program and what is done is there is a positive screen

A

Targets 50 - 74y.o. women.
Mammogram every two years.

Positive screen - triple test: Clinical, radiological and pathological exam

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2
Q

What abnormalities can be found on a breast mammogram?

A
  • Densities/masses
  • Distortions
  • Calcification
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3
Q

What abnormalities can be found on an ultrasound of the beast?

What is the advantage/disadvantage vs mammogram?

A
  • Cysts
  • Masses

Not good at detecting calcifications or distortions

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4
Q

Symptomatic presentation of benign breast disease?

A
  • Mass/lump
  • Pain
  • NIpple changes/discharges
  • Skin changes
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5
Q

How does risk of breast malignancy vary according to age?

A

6% <40

70% >50

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6
Q

Three nipple symptoms:

A
  • Galactorrhoea (increased fluid production)
  • Discharge (serous/bloody)
  • Crusting/itching
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7
Q

4 types of inflammatory breast disease:

A
  • Acute mastitis
  • Sub-areola abscess
  • Mammary duct ectasia
  • Fat necrosis
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8
Q

What is SMOLD?

A

Squamous metaplasia of lactiferous ducts (SMOLD) caused by obstruction/dilation.

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9
Q

What risk factor is sub-areolar abscesses (SMOLD) associated with?

A

Smoking - 90% of cases are smokers

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10
Q

List the 3 inflammatory breast disease that present with hot, red, swollen mass?

A

Acute mastitis

Sub-areolar abscess

Mammary duct ectasia

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11
Q

What is the name given to non-neoplastic change in breast epithelium?

A

Non-proliferative fibrocystic change

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12
Q

How are proliferative benign breast diseases classed?

A

As epithelial, stromal, or mixed elements of both.

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13
Q

What are the two types of epithalil proliferation benign breast disease?

How are they classed?

A

Epithelial hyperplasia

Columnar cell change

Both are classed based on atypia.

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14
Q

What is the stroma-only proliferative breast disease?

A

PASH - Pseudoangiomatous stromal hyperplasia.

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15
Q

What are the 4 types of proliferative breast disease that involve both epithelia and stroma?

A
  • Sclerosing adenosis
  • Complex sclerosing lesion
  • Papilloma
  • Fibroadenoma
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16
Q

What is breast carcinoma in situ and how is it classed?

A

In situ = malignant cells confined by an anatomical structure.

In this case, they are confined to the ductal lobular system without invasion.

Classification:

  • Ductal (DCIS)
  • Lobular (LCIS)
17
Q

Site and treatment differences in DCIS vs LCIS?

A

DCIS = confined to ducts

LCIS = confined to lobes

DCIS management = surgigcal excision with clear margins

LCIS management = excision at surgical margins

18
Q

Loss of which protein expression is hallmark of LCIS?

A

E-cadherin

19
Q

Which disease is strongly associated with DCIS, with red, weeping eczematous nipple?

How is it treated?

A

Paget’s disease.

Treated the same as DCIS.

20
Q

What are the prevalence of different types of invasive breast cancer?

A

Invasice ductal carcinoma (80%)

Invasive lobar carcinoma (10%)

21
Q

What are the rare types (2 each) with good and bad prognosis?

A

Good:

  • Mucinous
  • Tubular

Bad:

  • Micropapillary
  • Basal
22
Q

How is invasive breast cancer graded?

A

Nottingham grade:

Score/3 for:

  • Tubule formation
  • Nuclear atypia
  • Mitotic rate

SUmmed.

23
Q

Which biomarkers should be chekced in invasive breast cancer?

A

ER (estrogen receptor)
PR (progesterone receptor)

HER2 receptor

24
Q

Why is activation of ER/PR/HER2 significant in breast cancer?

How is it predictive for treatment?

A

These receptors give overexpressing malignant cells a growth advantage

ER+/PR+ responds better to anti-oestrogen therapy.

HER2+ = poor prognosis, HER2- is good. Strong predictor of anti-HER2 therapy.