Hepatitits Flashcards
Are the different hepatitis viruses closely related to each other from an evolutionary standpoint?
Nope
Do the different hepatitis viruses cause similar symptoms?
Yes because they all infect the hepatocytes
Which hepatitis viruses cause acute hepatitis? How do you treat acute hepatitis?
All of them! Treat with supportive care
Which hepatitis viruses are transmitted via the fecal-oral route?
A&E
Which hepatitis viruses are transmitted by sex/birth/blood?
B,C, & D
Which hepatitis viruses are controlled by vaccines?
A, B, & hopefully E
Which hepatitis virus has a high risk for bad outcomes but is dependent on Hep B for coinfection?
D
Is Hep B vaccination protective against Hep D?
Yes
HepA:
IgM = x
x = Acute Infection
HepA
IgG = x
x = Recovered/vaccinated
HepB
Viral surface antigen =
Acute
HepB
IgG against viral surface antigen =
Recovered/Vaccinated
HepC
EIA =
Real or False Postitve
HepC
RIBA =
Confirmation for Positive EIA
HepD
Delta Antigen =
Infection
Which hepatitis viruses can cause chronic infections which can lead to cirrhosis or cancer?
B&C
How do you treat chronic hepatitis?
Polymerase inhibitors and IFN
What’s the downside to treatment with Polymerase inhibitors and interferon?
Many side effects, often ineffective
What new medication may improvement treatment of serotype 1 (HepC)?
Protease inhibitors
What treatment alleviates liver failure?
Transplant
Under what circumstances will a transplanted liver become infected with a hepatitis virus?
If the virus was not cleared from a secondary site of infection
What may help clear infections from secondary sites before liver transplantation?
A short course of antivirals
What complicates treatment of Hepatitis B and C?
HIV infection
