hepatitis viruses Flashcards
hepatitis viruses target the ______.
liver
types of +ssRNA hep
A,C,E
types of -ssRNA hep
D
how is hep B’s genome arranged?
circular dsDNA - smallest human virus genome
all types of hep are transmitted via ______ and _______ however only HEV and HAV are transmitted ______ while the rest are transmitted ______
all= sexual, parenteral (intravenous) E,A = fecal-orally B,C,D = vertically (mother to embryo)
what virus family does ea. of the hep viruses belong to?
A - picornaviridae B - hepadnaviridae C - flaviviridae D - deltaviridae E - calciviridae
hep B biology
can't be cultured genome has RNA intermediate cccDNA is templte from transcription req. liver transciption factors produces empty particles found in infected people
hep B disease
thru sex and drug use
incubation 30-180 days
symptoms - malaise, anorexia, vomiting, fatigue, fough, serum-like sickness, jaundice and elevated ALT levels
hep B recovery
3-4 mo. after jaundice
chronic 5% of time from poor IgG resp.
chronic hep B can result in
cirrhosis of liver
inc. risk for hepatocellular carcinoma
hep B treatment
multiple vaccines
not effective against chronic infections (need interferon alpha therapy or nucleoside analogs
hep D virus has rare ______ b/c req. _______ and is unique b/c it’s RNA genome encodes ______
subviral agent
HBV infection
a single prot.
how does hep C virus get into a cell
endocytosed then the genome is passed into the cytoplasm
how is hep C virus disease diff from hep B
milder signs and symptoms
more often chronic
extrahepatic disease from antibody and virus complexes going to other organs and damaging them
no vaccine
how are HEV and HAV similar?
both foodborne/ingested
both incubation 15-40 days
both have sympt like HBV
both are non-chronic and have short term conditions
