Hepatitis C therapy

Question 1

Inhibits synthesis of guanine nucleotides by competively inhibiting inosine monophosphate dehydrogenase

Answer 1

Ribavirin

Question 2

Adverse effects of Ribavirin

Answer 2

Hemolytic anemia and severe teratogen

Question 3

Ribavirin indications

Answer 3

Chronic HCV and RSV

Question 4

Adverse effects of Sofosbuvir

Answer 4

Fatigue, headache, nausea

Question 5

Sofosbuvir indications

Answer 5

Chronic HCV

Question 6

Inhibits HCV RNA-dependent RNA polymerase acting as chain terminator

Answer 6

Sofosbuvir

Question 7

Sofosbuvir mechanism

Answer 7

Terminates RNA strand elongation by inhibiting HCV RNA-dependent RNA polymerase

Question 8

Ribavirin mechanism

Answer 8

Inhibits inosine monophosphate stopping synthesis of guanine nucleotides

Question 9

HCV drugs not used as monotherapy

Answer 9

Sofosbuvir and Simeprevir

Question 10

Combination therapy drugs used with Sofosbuvir

Answer 10

Ribavirin, simeprevir, ledipasvir +/- peginterferon alfa

Question 11

HCV therapy drug used in conjunction with Sofosbuvir and Simeprevir

Answer 11

Ledipasvir

Question 12

Mechanism of ledipasvir

Answer 12

NS5A inhibitor

Question 13

NS5A inhibitor used along with Sofosbuvir and Simeprevir

Answer 13

Ledipasvir

Question 14

Simeprevir indications

Answer 14

Chronic HCV

Question 15

Combination drugs used with Simeprevir

Answer 15

Ledipasvir

Question 16

Adverse effects of Simeprevir

Answer 16

Photosensitivity reactions, rash

Question 17

Simeprevir mechanism

Answer 17

HCV protease inhibitor - prevents viral replication

Question 18

HCV drugs

Answer 18

Ledipasvir, Simeprevir, Sofosbuvir, Ribavarin (LeSSoR)