Hepatitis Flashcards

1
Q

Why hepatitis type is caused by a DNA virus

A

Hepatitis B

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2
Q

Transmission of each hepatitis

A
A - faeco - oral 
B - sexual, vertical, parenteral
C - parenteral (IVDU)
D - parenteral, sexual 
E - faeco oral
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3
Q

Which hepatitis can be passed from mother to baby

A

Hepatitis B

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4
Q

Which hepatitis is chronic

A

Hepatitis C

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5
Q

Risk factor of hepatitis A

A

Travelling to Asia or Africa

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6
Q

Clinical feature of hepatitis

A
Symptoms 
RUQ pain 
Pruritis 
Nausea and vomiting 
Anorexia 
Joint pain 

Signs:
RUQ tenderness
Jaundice
Flu symptoms

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7
Q

Investigations

A

Abdominal examination
Obs
Bloods - LFTs, U+Es, FBC, CRP, prothrombin time, serology

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8
Q

Serology

A

Surface antigen - active infection
Surface antibody - immunity - past infection or vaccinated
Core IgM - acute infection
Core IgG - past infection
e antigen - infectious - active replication

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9
Q

Vaccinated serology

A

Surface antigen - negative
Surface antibody - positive
IgM - negative
IgG - negative

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10
Q

Chronic infection serology

A

Surface antigen - positive
Surface antibody - negative
IgM - negative
IgG - positive

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11
Q

Immune last infection serology

A

Surface antigen - negative
Surface antibody - positive
IgM - negative
IgG - positive

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12
Q

Acute infection serology

A

Surface antigen - positive
Surface antibody - negative
IgM - positive
IgG - positive

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13
Q

Definition of chronic hepatitis

A

Hepatitis lasting for 6 months or longer

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14
Q

Management of hepatitis

A

A - supportive care
B - antivirals - pegylated IFN- a (no cure)
C - antivirals +/- ribaviran

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15
Q

Hepatitis E risk factors

A

Farm animals

Immunocompromised

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16
Q

Complication of hepatitis

A

Chronic liver disease - cirrhosis

Hepatocellular carcinoma

17
Q

Most common worldwide and in Europe

A

Worldwide - B

Europe - C

18
Q

Which hepatitis has vaccine

A

Hep B

19
Q

Hereditary haemochromatosis

A

Inherited disorder resulting from abnormal

iron metabolism

20
Q

Hereditary haemochromatosis complications

A

Myocardial:

  • Dilated cardiomyopathy
  • Arrhythmias

Endocrine:
Pancreas: DM
Pituitary: hypogonadism → amenorrhoea, infertility

Parathyroid:

  • hypocalcaemia and osteoporosis
  • Arthritis- 2nd and 3rd MCP joints, knees and shoulders

Liver
Chronic liver disease → cirrhosis → HCC
Hepatomegaly

Skin:
Slate grey discolouration

21
Q

HHC Mx

A

Iron removal
- Venesection

General:

  • Monitor DM
  • Low Fe diet

Screening:
Se ferritin and genotype
Screen 1st degree relatives

Transplant in cirrhosis

22
Q

α1-Antitrypsin Deficiency

A

α1AT inhibits neutrophil elastase therefore deficiency causes increased elastase

α1AT is synthesised in the liver

  • Causes COPD in younger pts
23
Q

Ix of α1-Antitrypsin Deficiency

A
Blood: ↓ se α1AT levels
Liver biopsy: 
CXR: emphysematous changes
Spirometry: obstructive defect
Prenatal Dx: possible by CVS
24
Q

Wilson’s Disease

A

Mutation of Cu transporting ATPase
Impaired hepatocyte incorporation of Cu into
caeruloplasmin and excretion into bile.

Cu accumulation in liver and, later, other organs

25
Q

Wilson’s disease Ix

A
Bloods: ↓Cu, ↓caeruloplasmin
( may be high during infection) 
↑ 24h urinary Cu
Liver biopsy: ↑ hepatic Cu
MRI: basal-ganglia degeneration
26
Q

Rx for Wilson’s disease

A

Diet: avoid high Cu foods: liver, chocolate, nuts

Penicillamine lifelong (Cu chelator)

Monitor FBC and urinary Cu excretion

Liver Tx if severe liver disease

Screen siblings

27
Q

Diseases associated with AIH

A
Autoimmune thyroiditis
DM
Pernicious anaemia
PSC
UC
Glomerulonephritis
AIHA (Coombs +ve)