Hepatitis

Question 1

Is Hep A Self Limiting?

Does it have the capacity for acute disease?

Answer 1

Yes

No

Question 2

How is Hep A transmitted

Answer 2

Faeco Oral

Question 3

What are the symptoms of hepatitis

Answer 3

Jaundice

Flu-Like Symptoms

Hepatosplenomegaly

Question 4

Investigations for Hep A

Answer 4

High AST ALT and bilirubin

Question 5

Hep A Prophylaxis

Answer 5

Supportive

Prophylactic Vaccine

Question 6

Hepatitis B Route of Infection

Can it become Chronic?

Answer 6

Blood/Bodily Fluids
Mother to Infant

Yes

Question 7

What does HepBsAg indicate

Answer 7

Current Infection

Question 8

What does HepBsAb indicate

Answer 8

Natural Immunity

Question 9

HebBcIgM indication

Answer 9

Acute infection

Question 10

Heb B c Ab

Answer 10

Initially IgM, progresses to IgG after a few weeks

Question 11

Hep B e Ag

Answer 11

After s Ag, indicates a severe infectious nature

Question 12

Anti HB’s

Answer 12

Vaccinated Individual

Question 13

Heb B e Ab

Answer 13

Lower Viral Replication and Infectivity

Question 14

Treatment for Heb B

Answer 14

Supportive

for chronic it is antivirals and a transplant if there is cirrhosis

Question 15

Hepatitis C aetiology

Answer 15

Spread through blood
Most common hepatitis
High chance of chronic infection

Question 16

Hepatitis C specific symptoms

Answer 16

eye problems

rheumatological symptoms

Question 17

Investigations for Hep C

Answer 17

Patients at risk or have signs of chronic liver disease

test for Hep C virus

Negative = Not infected
Positive= Past or Active Infection

Test for Hep C Virus RNA by PCR

Positive: Current infection
Negative: Past Infection

Question 18

Treatment for Hep C

Answer 18

• Depends on the viral genotype
• Aim of treatment is sustaine virological response
• Protease inhibitor with or without ribavarin

Question 19

Hep D aetiology

Answer 19

Only occurs with Hep B
Exacerbates it very bacly
Transmitted through blood
Can be infected at same time (coinfection) or thr patient can develop it (Super infection)

Question 20

Hep E

Answer 20

No Vaccine
Faeco-oral/zoonosis
Doesnt progress to chronic liver disease and is self limiting

Question 21

Autoimmune hepatitis

Answer 21

Most commin in woman and appeares as piecemeal necrosis and lobular invilvement
unkown, however a classic example isa young woman on the pill.

Question 22

Treatment

Answer 22

Prednisolone
Azathiprine
US Acid if there is a PBC overlap for the itch
Liver Transplant.