Hepatitis Flashcards
Is Hep A Self Limiting?
Does it have the capacity for acute disease?
Yes
No
How is Hep A transmitted
Faeco Oral
What are the symptoms of hepatitis
Jaundice
Flu-Like Symptoms
Hepatosplenomegaly
Investigations for Hep A
High AST ALT and bilirubin
Hep A Prophylaxis
Supportive
Prophylactic Vaccine
Hepatitis B Route of Infection
Can it become Chronic?
Blood/Bodily Fluids
Mother to Infant
Yes
What does HepBsAg indicate
Current Infection
What does HepBsAb indicate
Natural Immunity
HebBcIgM indication
Acute infection
Heb B c Ab
Initially IgM, progresses to IgG after a few weeks
Hep B e Ag
After s Ag, indicates a severe infectious nature
Anti HB’s
Vaccinated Individual
Heb B e Ab
Lower Viral Replication and Infectivity
Treatment for Heb B
Supportive
for chronic it is antivirals and a transplant if there is cirrhosis
Hepatitis C aetiology
Spread through blood
Most common hepatitis
High chance of chronic infection
Hepatitis C specific symptoms
eye problems
rheumatological symptoms
Investigations for Hep C
Patients at risk or have signs of chronic liver disease
test for Hep C virus
Negative = Not infected Positive= Past or Active Infection
Test for Hep C Virus RNA by PCR
Positive: Current infection
Negative: Past Infection
Treatment for Hep C
- Depends on the viral genotype
- Aim of treatment is sustaine virological response
- Protease inhibitor with or without ribavarin
Hep D aetiology
Only occurs with Hep B
Exacerbates it very bacly
Transmitted through blood
Can be infected at same time (coinfection) or thr patient can develop it (Super infection)
Hep E
No Vaccine
Faeco-oral/zoonosis
Doesnt progress to chronic liver disease and is self limiting
Autoimmune hepatitis
Most commin in woman and appeares as piecemeal necrosis and lobular invilvement
unkown, however a classic example isa young woman on the pill.
Treatment
Prednisolone
Azathiprine
US Acid if there is a PBC overlap for the itch
Liver Transplant.
