Hepatitis Flashcards
Name 4 common symptoms of Hepatitis
Yellow Sclera / jaundice / dark urine / pale stools
Hepatitis A virus is part of what family?
Picornaviridae
Structure of Hepatitis A
Naked ssRNA
Icosahedral
27nm
Incubation of Hepatitis A
10-50 day
90% of cases of Hepatitis A are of what age?
5-15 years
What sort of vaccine is given for Hepatitis A
Monovalent inactivated Vaccine
Hepatitis B is part of what family?
Hepadnaviridae
What is the structure of Hepatitis B
how many genotypes
Partial dsDNA
9 genotypes
How many people are unaware of being infected with Hepatitis B? How many are infected at birth?
90%
75%
Incubation time for hepatitis B?
30-180 days
Name the 3 stages of hepaittis infection
Acute
Fulminant
Chronic
Name 2 treatments for Hepatitis B
IF-a
Tenofovir
Hepatitis D is what sort of virus?
subviral satellite
Structure of Hepatitis D
Delta genus
ssRNA
35-37nm
How many genotypes does hepatitis D have
3 genotypes
What % of Hep B patients have Hep D?
5%
What are the two complications of hepatitis D
Co-infection
Superinfection
Hepatitis C is part of what family?
Flaviviridae
Structure of hepatitis C
50nm
ssRNA enveloped
How many genotypes of hepatitis C
7 genotypes
How many are unaware of inefction of hepatitis C
80%
Where is the majority of Hep C infections?
Whats happening in the UK?
Africa
Increased
How many people are infected with Hep C in UK? Reference?
200,000 Gov 2018
What is the incubation time for Hepatitis C
What 3 things can it lead to?
8 weeks
Mild liver disease //chronic hep (90%) // cirrhosis
What Treatment can be given for hep C?
What is the probability of relapse?
IFN a2b
50/50
What sort of IFN can be given for Hep C
PEGylated IFNs
Name a nucleoside analogue for Hepatitis C
What does it do
Sofosbuvir
Inhibit polymerase
Name a protease inhibitor for hepatitis C
Simeprevir
What family is hepatitis E part of
hepeviridae
What is the structure of hep E
ssRNA
32-34nm
What genotypes are present with hepatitis E
How are these transmitted
G1 + G2 = faecal oral
G3 + G4 = Zoonotic
Hepatitis E is prevalent Where?
Endemic in developing countries
What is the incubation of hepatitis E
What normally happens to it
15-60 days
acute infection = lifelong immunity as self limiting
What age group is affected with hepatitis E
15-40
What happens to immunosuppresed individuals with hepatitis E
What happens to pregnant women with hepatitis E
Chronic Hepatitis
Fulminant Hepatitis
What genotype of hepatitis E has the highest mortality
G1
Whats the treatment for hepatitis E
no vaccine available
good sanitation
Ribavinin
Hepatitis G is part of what family like hepatitis C
Flaviviridae
What does it do to do with HIV
what does it not cause
decrease CXCR4 / CCR5 expression on CD4/CD19 B
disease
How many are infected with Hepatitis A
1.4 million
How many are infected with Hepatitis B
257million
How many are infected with Hepatitis D
15-20 million
How many are infected with Hepatitis C
71 million
How many are infected with Hepatitis E
20 million
Who are generally affected by Hepatitis A?
Travellers
What 2 hepatitis are transmitted by faecal oral?
A + E
With hepatitis A, what is it always in terms of stages/
normally always acute not chronic
With the diagnostics, what does a high IgM show?
Active infection
What two viruses have been associated with hepatitis that are not direct causes?
Torque Teno Virus
SEN-V
TTV is associated with what % of hepatitis disease patients/
16-19%
SEN-V is associated with what type of infection?
Co-infection of Hep . C
How can you treat SEV-V?
IFN
Structure of SEN-V
ssDNA
