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Kingstn 3rd year Section 2 > Hepatitis > Flashcards

Hepatitis Flashcards

1
Q

Name 4 common symptoms of Hepatitis

A

Yellow Sclera / jaundice / dark urine / pale stools

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2
Q

Hepatitis A virus is part of what family?

A

Picornaviridae

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3
Q

Structure of Hepatitis A

A

Naked ssRNA

Icosahedral

27nm

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4
Q

Incubation of Hepatitis A

A

10-50 day

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5
Q

90% of cases of Hepatitis A are of what age?

A

5-15 years

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6
Q

What sort of vaccine is given for Hepatitis A

A

Monovalent inactivated Vaccine

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7
Q

Hepatitis B is part of what family?

A

Hepadnaviridae

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8
Q

What is the structure of Hepatitis B

how many genotypes

A

Partial dsDNA

9 genotypes

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9
Q

How many people are unaware of being infected with Hepatitis B? How many are infected at birth?

A

90%

75%

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10
Q

Incubation time for hepatitis B?

A

30-180 days

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11
Q

Name the 3 stages of hepaittis infection

A

Acute

Fulminant

Chronic

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12
Q

Name 2 treatments for Hepatitis B

A

IF-a

Tenofovir

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13
Q

Hepatitis D is what sort of virus?

A

subviral satellite

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14
Q

Structure of Hepatitis D

A

Delta genus

ssRNA

35-37nm

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15
Q

How many genotypes does hepatitis D have

A

3 genotypes

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16
Q

What % of Hep B patients have Hep D?

A

5%

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17
Q

What are the two complications of hepatitis D

A

Co-infection

Superinfection

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18
Q

Hepatitis C is part of what family?

A

Flaviviridae

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19
Q

Structure of hepatitis C

A

50nm

ssRNA enveloped

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20
Q

How many genotypes of hepatitis C

A

7 genotypes

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21
Q

How many are unaware of inefction of hepatitis C

A

80%

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22
Q

Where is the majority of Hep C infections?

Whats happening in the UK?

A

Africa

Increased

23
Q

How many people are infected with Hep C in UK? Reference?

A

200,000 Gov 2018

24
Q

What is the incubation time for Hepatitis C

What 3 things can it lead to?

A

8 weeks

Mild liver disease //chronic hep (90%) // cirrhosis

25
Q

What Treatment can be given for hep C?

What is the probability of relapse?

A

IFN a2b

50/50

26
Q

What sort of IFN can be given for Hep C

A

PEGylated IFNs

27
Q

Name a nucleoside analogue for Hepatitis C

What does it do

A

Sofosbuvir

Inhibit polymerase

28
Q

Name a protease inhibitor for hepatitis C

A

Simeprevir

29
Q

What family is hepatitis E part of

A

hepeviridae

30
Q

What is the structure of hep E

A

ssRNA

32-34nm

31
Q

What genotypes are present with hepatitis E

How are these transmitted

A

G1 + G2 = faecal oral

G3 + G4 = Zoonotic

32
Q

Hepatitis E is prevalent Where?

A

Endemic in developing countries

33
Q

What is the incubation of hepatitis E

What normally happens to it

A

15-60 days

acute infection = lifelong immunity as self limiting

34
Q

What age group is affected with hepatitis E

A

15-40

35
Q

What happens to immunosuppresed individuals with hepatitis E

What happens to pregnant women with hepatitis E

A

Chronic Hepatitis

Fulminant Hepatitis

36
Q

What genotype of hepatitis E has the highest mortality

A

G1

37
Q

Whats the treatment for hepatitis E

A

no vaccine available

good sanitation

Ribavinin

38
Q

Hepatitis G is part of what family like hepatitis C

A

Flaviviridae

39
Q

What does it do to do with HIV

what does it not cause

A

decrease CXCR4 / CCR5 expression on CD4/CD19 B

disease

40
Q

How many are infected with Hepatitis A

A

1.4 million

41
Q

How many are infected with Hepatitis B

A

257million

42
Q

How many are infected with Hepatitis D

A

15-20 million

43
Q

How many are infected with Hepatitis C

A

71 million

44
Q

How many are infected with Hepatitis E

A

20 million

45
Q

Who are generally affected by Hepatitis A?

A

Travellers

46
Q

What 2 hepatitis are transmitted by faecal oral?

A

A + E

47
Q

With hepatitis A, what is it always in terms of stages/

A

normally always acute not chronic

48
Q

With the diagnostics, what does a high IgM show?

A

Active infection

49
Q

What two viruses have been associated with hepatitis that are not direct causes?

A

Torque Teno Virus

SEN-V

50
Q

TTV is associated with what % of hepatitis disease patients/

A

16-19%

51
Q

SEN-V is associated with what type of infection?

A

Co-infection of Hep . C

52
Q

How can you treat SEV-V?

A

IFN

53
Q

Structure of SEN-V

A

ssDNA

Kingstn 3rd year Section 2 (6 decks)

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